P.809 Correlation between childhood autism rating scale 2 and clinical global impression improvement

Falissard, B.; Severo, Cristina Albarrán; Lambert, Estelle V.; Crutel, Véronique; Kyaga, Simon; Serret, S.; Ravel, Denis; Lemonnier, Éric

doi:10.1016/j.euroneuro.2019.09.674

Cited by 4 publications

(5 citation statements)

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“…In the Phase IIa study, CARS was able to capture both improvement with bumetanide treatment and also loss of improvement when treatment was stopped. The improvement in CARS2 total score was recently shown to be strongly correlated with the CGI-I scale (Falissard et al 2019 ), which is a well-established tool for measuring clinical improvement in mental disorders. CARS2 can therefore be considered a valid tool for assessing clinical changes of ASD patients in both clinical trials and routine clinical care (Falissard et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…The improvement in CARS2 total score was recently shown to be strongly correlated with the CGI-I scale (Falissard et al 2019 ), which is a well-established tool for measuring clinical improvement in mental disorders. CARS2 can therefore be considered a valid tool for assessing clinical changes of ASD patients in both clinical trials and routine clinical care (Falissard et al 2019 ). An additional benefit to the use of CARS2 as the primary endpoint is that it is completed by an independent assessor rather than by parents/guardians (as for scales such as SRS).…”

Section: Discussionmentioning

confidence: 99%

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Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials)

Crutel

Lambert

Penelaud

et al. 2020

J Autism Dev Disord

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There are currently no approved pharmacological treatments to improve social reciprocity and limit repetitive and rigid behaviors in autism spectrum disorder (ASD). We describe the design of two Phase III studies evaluating the efficacy/safety of bumetanide oral liquid formulation in ASD. These are international, multicenter, randomized, double-blind, placebo-controlled studies in children and adolescents with ASD aged 7 to 17 years (n = 200; study 1), or younger children with ASD aged 2 to 6 years (n = 200; study 2). The primary endpoint of each is change in Childhood Autism Rating Scale 2 total raw score after 6 months. These studies could contribute to the first pharmacological treatment to improve social reciprocity and limit repetitive and rigid behaviors in children and adolescents with ASD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials)

Crutel

Lambert

Penelaud

et al. 2020

J Autism Dev Disord

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“…The CARS is one of the most important tools for the assessment of ASD, such that both clinical and research practices often use it[ 31 ]. Recently, CARS-2 was exploited based on the original edition of the CARS[ 32 ]. CARS-2 (normalized form) is the same as original the CARS, whereas CARS-2-HF (high-functioning form) is a newly developed optional diagnostic for evaluating ASD in children over a certain age and with intelligence quotient (IQ) scores above 80[ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of diagnostic validity of two autism rating scales for suspected autism in a large Chinese sample

Chu¹,

Bian²,

Yan³

et al. 2022

WJCC

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BACKGROUND Autism is the most common clinical developmental disorder in children. The childhood autism rating scale (CARS) and autistic autism behavior checklist (ABC) are the most commonly used assessment scales for diagnosing autism. However, the diagnostic validations and the corresponding cutoffs for CARS and ABC in individuals with suspected autism spectrum disorder (ASD) remain unclear. Furthermore, for suspected ASD in China, it remains unclear whether CARS is a better diagnostic tool than ABC. Also unclear is whether the current cutoff points for ABC and CARS are suitable for the accurate diagnosis of ASD. AIM To investigate the diagnostic validity of CARS and ABC based on a large Chinese sample. METHODS A total of 591 outpatient children from the ASD Unit at Beijing Children’s Hospital between June and November 2019 were identified. First, the Clancy autism behavior scale (CABS) was used to screen out suspected autism from these children. Then, each suspected ASD was evaluated by CARS and ABC. Receiver operating characteristic (ROC) curve analysis was used to compare diagnostic validations. We also calculated the area under the curve (AUC) for both CARS and ABC. RESULTS We found that the Cronbach alpha coefficients of CARS and ABC were 0.772 and 0.426, respectively. Therefore, the reliability of the CARS was higher than that of the ABC. In addition, we found that the correlation between CARS and CABS was 0.732. Next, we performed ROC curve analysis for CARS and ABC, which yielded AUC values of 0.846 and 0.768, respectively. The cutoff value, which is associated with the maximum Youden index, is usually applied as a decision threshold. We found that the cutoff values of CARS and ABC were 34 and 67, respectively. CONCLUSION This result indicated that CARS is superior to ABC in the Chinese population with suspected ASD.

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“…CARS is one of the most important tools for the assessment of ASD, such that both clinical and research practices often use it [23]. Recently, CARS-2 was exploited based on the original edition of CARS [24]. CARS-2 (normalized form) is the same as original CARS, whereas CARS-2-HF (high-functioning form) is a newly developed optional diagnostic for evaluating ASD in children over a certain age and with IQ scores above 80 [25].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Autistic Behavior Checklist and the Childhood Autism Rating Scale for Suspected Autism in a Large Chinese Sample

Chu

Bian

Yan

et al. 2020

Preprint

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Autism is the most common clinical developmental disorder in children. The Childhood Autism Rating Scale (CARS) and Autistic Behavior Checklist (ABC) are the most commonly used assessment scales for diagnosing autism. The aim of this study is to compare the diagnostic validities of CARS and ABC based on a large Chinese sample. A total of 474 children with suspected autism spectrum disorder (ASD) were screened by CARS and ABC. Receiver operating characteristic (ROC) curve analysis was performed and it showed that the area-under-the-curve values of CARS is higher than ABC significantly (p < 0.05) and the suggested cutoff values of CARS and ABC were 34 and 67, respectively. It indicated that CARS is superior to ABC in the Chinese population with suspected ASD.

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P.809 Correlation between childhood autism rating scale 2 and clinical global impression improvement

Cited by 4 publications

References 1 publication

Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials)

Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials)

Comparison of diagnostic validity of two autism rating scales for suspected autism in a large Chinese sample

A Comparison of the Autistic Behavior Checklist and the Childhood Autism Rating Scale for Suspected Autism in a Large Chinese Sample

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