P.82 How effective is salvage of infected intravenousfeeding catheters?

Ward, Sarah; Carlson, Gerald L.; Anderson, ID; Shaffer, Jon; Irving, M. H.

doi:10.1016/s0261-5614(97)80206-3

Cited by 1 publication

(1 citation statement)

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“…This led to the policy of CVC removal after the occurrence of a second CRBSI. The unpublished study of Ward et al ( 60 ) found that catheter salvage was more likely to fail in CRBSIs with S. aureus . Patients were treated with either systemic antibiotics only or in combination with ALT.…”

Section: Resultsmentioning

confidence: 99%

Comparing success rates in central venous catheter salvage for catheter-related bloodstream infections in adult patients on home parenteral nutrition: a systematic review and meta-analysis

Gompelman

Paus

Bond

et al. 2021

The American Journal of Clinical Nutrition

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Background Catheter-related bloodstream infection (CRBSI) is a life-threatening complication of parenteral nutrition. Therefore, optimal management, ideally with catheter salvage, is required to maintain long-term venous access. Objectives We aimed to evaluate successful catheter salvage rates in patients on home parenteral nutrition (HPN). Methods Studies were retrieved from medical databases, conference proceedings, and article reference lists. Data were collected relating to clinical outcomes of 3 treatments: systemic antibiotics, antimicrobial lock therapy (ALT), and catheter exchange. ORs and 95% CIs were calculated from a mixed logistic effects model. Results From 10,036 identified publications, 28 met the inclusion criteria (22 cohort studies, 5 case-control studies, and 1 randomized clinical trial), resulting in a total of 4911 CRBSIs. To achieve successful catheter salvage, the addition of an antimicrobial lock solution was superior to systemic antibiotics alone (OR: 1.75; 95% CI: 1.21, 2.53; P = 0.003). Recurrence of infection was less common in studies that used ALT than in those that used systemic antibiotics alone (OR: 0.26; 95% CI: 0.11, 0.61; P = 0.002). The catheter exchange group was excluded from multilevel regression analysis because only 1 included study applied this treatment. Successful salvage rates were highest for coagulase-negative staphylococci, followed by Gram-negative rods and Staphylococcus aureus . Conclusions The addition of an antimicrobial lock solution seems beneficial for successful catheter salvage in HPN-dependent patients with a CRBSI. Future prospective randomized studies should identify the most effective and pathogen-specific strategy. This review was registered at www.crd.york.ac.uk/PROSPERO as CRD42018102959.

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Section: Resultsmentioning

confidence: 99%