p-Benzoquinone initiates non-invasive urothelial cancer through aberrant tyrosine phosphorylation of EGFR, MAP kinase activation and cell cycle deregulation: Prevention by vitamin C

Ganguly, Shinjini; Chandra, Ayan; Chattopadhyay, D.; Chatterjee, Indu B.

doi:10.1016/j.toxrep.2017.06.005

Cited by 6 publications

(8 citation statements)

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“…Like that reported before with p-BQ treatment [ 4 ], we observed that CS exposure caused significant (p < 0.001) protein oxidation and apoptosis (p < 0.001) in the renal pelvis up to 4 weeks of exposure ( Fig. 2 ).…”

Section: Resultssupporting

confidence: 86%

“…Earlier we had shown that p-BQ in amounts available from CS exposure caused carcinoma in situ (CIS) in the renal pelvis of guinea pigs that was prevented by oral administration of vitamin C (30 mg/kg body weight/day). p-BQ closely mimicked CS for producing oxidative damage, apoptosis, persistent proliferation and cell cycle degradation in the renal pelvis leading to development of CIS [ 4 ]. However, in contrast to CS-induced CRP (stage pT1), which is an invasive cancer, p-BQ-induced CIS is a noninvasive cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Using a vitamin C-restricted guinea pig model, earlier we had shown that prolonged treatment (intramuscular injection) for 24 weeks with p-benzoquinone (p-BQ) produced carcinoma in situ (CIS) in the renal pelvis, a noninvasive cancer [ 4 ]. Although p-benzoquinone is not present in CS, it is produced from benzosemiquinone (p-BSQ) of CS by oxidation and disproportionation [ 4 ]. p-BSQ is present in substantial amounts (100–200 μg) in CS [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although p-benzoquinone is not present in CS, it is produced from benzosemiquinone (p-BSQ) of CS by oxidation and disproportionation [ 4 ]. p-BSQ is present in substantial amounts (100–200 μg) in CS [ 4 ]. Since, besides p-BSQ, CS is a complex mixture of more than 4000 compounds, including a number of oxidants, toxic chemicals and carcinogens [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…We therefore investigated the effect of CS exposure to the guinea pigs. We used the guinea pig model because of its similarity with CS-induced pathophysiology of humans, the details of which are given elsewhere [ 4 ]. Here, we showed that CS exposure produced invasive tumor (pT1) that has penetrated the basement membrane to invade the lamina propria in the renal pelvis.…”

Section: Introductionmentioning

confidence: 99%

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Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C

2018

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C

2018

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L-ascorbic acid and α-tocopherol treatment alleviates parabenzoquinone-induced hemato-biochemical and histopathological changes in Wistar rats

Mishra

Dutta²,

Bharali³

2022

Toxicol. Environ. Health Sci.

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The effect of antioxidants in acute amitriptyline poisoning

Ali

Raja

2019

Toxicology Reports

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Objective To study the effect of Antioxidants supplementation in reducing oxidative stress induced in acute amitriptyline poisoning cases. Design and methods We compared the effect of supplementation of treatment of acute amitriptyline poisoning cases with alpha lipoic acid alone or with vitamin C, with that of those receiving only routine standard treatment (RST) as a control group. A total of 132 subjects divided into 5 groups were selected from IMCU (Intensive Medical Care Unit) and Toxicology Ward, Govt. General Hospital, Chennai, India. The study was restricted to grade 1 coma in poisoned subjects per the Edinburg scale. Each of the subjects was in the groups were supplemented with either placebo, RST, RST with vitamin C, RST with ALA, or RST with vitamin C and ALA. Acute anti-depressant poisoning (especially with amitriptyline) induced oxidative stress caused lipid peroxidation. Plasma cholinesterases (chE) play a major role in combating this effect. A determination of the level of cholinesterase (chE) acts as an indirect indicator of the level of oxidative stress and a measure of the efficacy of antioxidant supplementation. Plasma cholinesterase estimation was done by colorimetric method. The change in color of the indicator bromothymol blue caused by the liberated acetic acid from cholinesterase read by spectrophotometer at 620 nm was used to determine the levels of cholinesterase. Result A decrease in the level of oxidative stress was observed among those supplemented with either alpha lipoic acid alone or along with vitamin C, with a slightly more decrease in oxidative stress in the latter group. A p-value of <0.001 is considered significant statistically. The percentage of the benefit of treatment on supplementation with vitamin C and alpha lipoic acid showed a marked increase in group V (26.9%) cases after supplementation with both in combination. Conclusion The results provide evidence that the oxidative stress induced by acute amitriptyline poisoning is comparatively decreased by supplementation with antioxidants like alpha lipoic acid and vitamin C, than those only on routine standard treatment.

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p-Benzoquinone initiates non-invasive urothelial cancer through aberrant tyrosine phosphorylation of EGFR, MAP kinase activation and cell cycle deregulation: Prevention by vitamin C

Abstract: Graphical abstract

Cited by 6 publications

References 64 publications

Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C

Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C

L-ascorbic acid and α-tocopherol treatment alleviates parabenzoquinone-induced hemato-biochemical and histopathological changes in Wistar rats

The effect of antioxidants in acute amitriptyline poisoning

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