P-coumaric acid ameliorates Aβ25–35-induced brain damage in mice by modulating gut microbiota and serum metabolites

Cao, Bing; Zeng, Meng-nan; Hao, Feng-xiao; Hao, Zhi-you; Zhang, Zhen-kai; Liang, Xi-wen; Wu, Yuan-yuan; Zhang, Yu-han; Feng, Wei-sheng; Zheng, Xiao-ke

doi:10.1016/j.biopha.2023.115825

Cited by 7 publications

(1 citation statement)

References 71 publications

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“…When the gut homeostasis is compromised, anti-inflammatory molecules such as SCFAs are decreased and an imbalance occurs with levels of pro-inflammatory molecules (e.g., LPS or biofilm amyloid fibres) [97,98] resulting in greater permeability of the intestinal wall, increased mitochondrial ROS production, neuronal peroxisome proliferation, as well as neurotoxin aggregation and, potentially, neurodegeneration. The decline in free radicals in the brain, through the reduction of oxidation by the modulation of the gut microbiome with the consumption of (poly)phenolic compounds, is reflected by the decrease in the level of malondialdehyde (MDA) and ROS, which is concordant with the changes in SCFAs production or the increase in SCFA-producing bacteria in several studies [74,80,82,85,[99][100][101][102][103][104][105][106] (Table 1). This interplay between gut microbiota and brain oxidative stress highlights the potential of the gut microbiome to modulate the brain redox status.…”

Section: Insight Into Associated Molecular Mechanismsmentioning

confidence: 63%

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Láng,

McArthur,

Lazar

et al. 2024

Nutrients

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As the population ages, the incidence of age-related neurodegenerative diseases is rapidly increasing, and novel approaches to mitigate this soaring prevalence are sorely needed. Recent studies have highlighted the importance of gut microbial homeostasis and its impact on brain functions, commonly referred to as the gut–brain axis, in maintaining overall health and wellbeing. Nonetheless, the mechanisms by which this system acts remains poorly defined. In this review, we will explore how (poly)phenols, a class of natural compounds found in many plant-based foods and beverages, can modulate the gut–brain axis, and thereby promote neural health. While evidence indicates a beneficial role of (poly)phenol consumption as part of a balanced diet, human studies are scarce and mechanistic insight is still lacking. In this regard, we make the case that dietary (poly)phenols should be further explored to establish their therapeutic efficacy on brain health through modulation of the gut–brain axis, with much greater emphasis on carefully designed human interventions.

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