“…The 3D plot of the binding sites and the 2D plot of interactions of Cyclin E with (C) 1, 2-benzene dicarboxylic acid, diisooctyl ester, and (D) 3,4-Dihydro-1h-isoquinoline-2-carboxamidine hydrochloride, Figure S6: The 3D plot of the binding sites and the 2D plot of interactions of HIF-1α with (A) 6,10-Dimethyldodeca-5,9-dien-2-one, and (B) 1, 2-benzene dicarboxylic acid, diisooctyl ester. The 3D plot of the binding sites and the 2D plot of interactions of TERT with (C) 1, 2-benzene dicarboxylic acid, diisooctyl ester, and (D) 3,4-Dihydro-1h-isoquinoline-2-carboxamidine hydrochloride, Figure S7: The 3D plot of the binding sites and the 2D plot of interactions of p21 with (A) 3,4-Dihydro-1h-isoquinoline-2-carboxamidine hydrochloride, (B) Azulene, (C) Benzene 1-ethyl-3-methyl-, (D) D-glucose, cyclic ethylene mercaptan, pentaacetate, and E) Phenol,2,4-bis(1,1dimethylethyl)-, Figure S8: The 3D plot of the binding sites and the 2D plot of interactions of PCNA with (A) (5E,9E)-6,10-Dimethyldodeca-5,9-dien-2-one, (B) 3,4-Dihydro-1h-isoquinoline-2-carboxamidine hydrochloride, (C) Benzene 1-ethyl-3-methyl-, (D) Cyclooctaneacetic acid, 2-oxo-, and (E) Cycloundecene,1-methyl-, Figure S9: The original gels of western blot analysis, Table S1: GC-MS compounds in aqueous extract of sea cucumber ( Holothuria parva ) based on PubChem database, Table S2: The values of binding affinity (Kcal/mol) of ligands to receptors [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ,…”