2014
DOI: 10.2147/dddt.s61024
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P-glycoprotein- and organic anion-transporting polypeptide-mediated transport of periplocin may lead to drug–herb/drug–drug interactions

Abstract: Periplocin, an active and toxic component of the traditional Chinese herbal medicine Periploca sepium Bge, is a cardiac glycoside compound that has been implicated in various clinical accidents. This study investigated the role of transporters in the intestinal absorption and biliary excretion of periplocin, as well as the possible metabolic mechanism of periplocin in liver S9. In a bidirectional transport assay using Madin–Darby canine kidney (MDCK) and MDCK multidrug-resistance protein (MRP)-1 cell monolayer… Show more

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Cited by 6 publications
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“…Both herbs share similar morphological characteristics and name (Figure 1 ), but the functions and efficacies of these herbs are not quite the same. Periplocae cortex contains toxic components that may cause poisoning and has been implicated in various clinical accidents (Liang et al, 2014 ). Acanthopanax gracilistylus wine poisoning has been reportedly caused by Periplocae cortex substitution for Acanthopanacis cortex.…”
Section: Introductionmentioning
confidence: 99%
“…Both herbs share similar morphological characteristics and name (Figure 1 ), but the functions and efficacies of these herbs are not quite the same. Periplocae cortex contains toxic components that may cause poisoning and has been implicated in various clinical accidents (Liang et al, 2014 ). Acanthopanax gracilistylus wine poisoning has been reportedly caused by Periplocae cortex substitution for Acanthopanacis cortex.…”
Section: Introductionmentioning
confidence: 99%