P-Hydroxyacetophenone Ameliorates Alcohol-Induced Steatosis and Oxidative Stress via the NF-κB Signaling Pathway in Zebrafish and Hepatocytes

Huang, Sha; Zhou, Chuying; Zeng, Ting; Li, Yujia; Lai, Yuqi; Mo, Chan; Chen, Yuyao; Huang, Shaohui; Lv, Zhen; Gao, Lei

doi:10.3389/fphar.2019.01594

Cited by 18 publications

(6 citation statements)

References 49 publications

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“…33 Recently, hydroxylacetophenone was reported to exhibit hepatoprotective, anti-inflammatory, and antioxidant effects. 46 A new, naturally occurring active auxin was detected and annotated as phenylacetic acid-O-rutinoside, S5). Auxins are phytohormones responsible for plant growth and play an important role in the protection against various external biotic and abiotic stresses.…”

Section: Resultsmentioning

confidence: 98%

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UPLC-MS Metabolome-Based Seed Classification of 16 Vicia Species: A Prospect for Phyto-Equivalency and Chemotaxonomy of Different Accessions

Fayek

Mekky

Dias

et al. 2021

J. Agric. Food Chem.

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Seeds of domesticated Vicia (vetch) species (family Fabaceae-Faboideae) are produced and consumed worldwide for their nutritional value. Seed accessions belonging to 16 different species of Viciaboth domesticated and wild taxawere subjected to a chemotaxonomic study using ultraperformance liquid chromatography–mass spectrometry (UPLC-MS) analyzed by chemometrics. A total of 89 metabolites were observed in the examined Vicia accessions. Seventy-eight out of the 89 detected metabolites were annotated. Metabolites quantified belonged to several classes, viz., flavonoids, procyanidins, prodelphinidins, anthocyanins, stilbenes, dihydrochalcones, phenolic acids, coumarins, alkaloids, jasmonates, fatty acids, terpenoids, and cyanogenics, with flavonoids and fatty acids amounting to the major classes. Flavonoids, fatty acids, and anthocyanins showed up as potential chemotaxonomic markers in Vicia species discrimination. Fatty acids were more enriched in Vicia faba specimens, while the abundance of flavonoids was the highest in Vicia parviflora. Anthocyanins allowed for discrimination between Vicia hirsuta and Vicia sepium. To the best of our knowledge, this is the first report on employing UPLC-MS metabolomics to discern the diversity of metabolites at the intrageneric level among Vicia species.

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Section: Resultsmentioning

confidence: 98%

“…Only one hydroxylacetophenone was detected and annotated as trihydroxacetophenone-di- C -hexoside (peak 21) . Recently, hydroxylacetophenone was reported to exhibit hepatoprotective, anti-inflammatory, and antioxidant effects …”

Section: Resultsmentioning

confidence: 99%

UPLC-MS Metabolome-Based Seed Classification of 16 Vicia Species: A Prospect for Phyto-Equivalency and Chemotaxonomy of Different Accessions

Fayek

Mekky

Dias

et al. 2021

J. Agric. Food Chem.

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“…Recently Ching-Wen et al demonstrated that this compound has anti-inflammatory and antinociceptive activities [ 33 ]. Other authors mentioned that due to antioxidant and anti-inflammatory effects of compounds, chemicals related with p-hydroxy acetophenone could be use as hepatoprotective compounds [ 34 ]. Later Neng-Hua et al [ 35 ] isolated 10 acetophenones from Acronychia oligoplebia and studied their anti-inflammatory and antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Activity of 3, 5-Diprenyl-4-hydroxyacetophenone Isolated from Ageratina pazcuarensis

Rojas-Jiménez

Pérez-Gutiérrez

Sánchez-Mendoza

et al. 2022

IJMS

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Inflammation is implicated in a wide variety of physiological and pathological processes. Plants are an important source of active anti-inflammatory compounds. The compound 3, 5-diprenyl-4-hydroxyacetophenone (DHAP) was isolated from the dichloromethane extract of the aerial parts of Ageratina pazcuarensis by chromatography and identified by spectroscopic (IR, NMR) and spectrometric (GC-MS) methods. Anti-inflammatory activity was evaluated on ear edema mouse induced with 12-O-tetradecanoylphorbol 13-acetate (TPA) at 2 mg/ear. The antioxidant activity of DHAP was determined using DPPH assay. Cell viability was tested in J774A.1 macrophages, the levels of NO, TNF-α, IL-1β, IL-6, and IL-10 production in macrophages stimulated with lipopolysaccharide (LPS), and membrane lysis induced by hypotonic solution in erythrocytes were evaluated. DHAP diminished the ear edema mouse in 70.10%, and it had scavenger effect against the radical with IC50 of 26.00 ± 0.37 µg/mL. Likewise, 91.78 µM of this compound inhibited the production of NO (38.96%), IL-1β (55.56%), IL-6 (51.62%), and TNF-α (59.14%) in macrophages and increased the levels of IL-10 (61.20%). Finally, 25 and 50 µg/mL DHAP provided the greatest protection against erythrocyte membrane lysis. These results demonstrate that DHAP has anti-inflammatory activity.

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“…It has been found to possess hepatoprotective, antioxidative, and anti-inflammatory properties, making it a potential treatment for alcoholic liver disease. It has also demonstrated antioxidative, antinociceptive, and anti-inflammatory effects, suggesting its therapeutic potential in inflammation-associated diseases [61]. Both 128 and 129 exhibited trypanocidal activities against Trypanosoma cruzi parasite.…”

Section: Asteraceaementioning

confidence: 99%

Natural-derived acetophenones: chemistry and pharmacological activities

Ahmadpourmir,

Attar,

Asili

et al. 2024

Nat. Prod. Bioprospect.

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Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities. Herein, we review the chemistry and biological activity of natural acetophenone derivatives that have been isolated and identified until January 2024. Taken together, it was reported 252 acetophenone derivatives in which the genera Melicope (69) and Acronychia (44) were the principal species as producers of acetophenones. Graphical Abstract

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P-Hydroxyacetophenone Ameliorates Alcohol-Induced Steatosis and Oxidative Stress via the NF-κB Signaling Pathway in Zebrafish and Hepatocytes

Cited by 18 publications

References 49 publications

UPLC-MS Metabolome-Based Seed Classification of 16 Vicia Species: A Prospect for Phyto-Equivalency and Chemotaxonomy of Different Accessions

UPLC-MS Metabolome-Based Seed Classification of 16 Vicia Species: A Prospect for Phyto-Equivalency and Chemotaxonomy of Different Accessions

Anti-Inflammatory Activity of 3, 5-Diprenyl-4-hydroxyacetophenone Isolated from Ageratina pazcuarensis

Natural-derived acetophenones: chemistry and pharmacological activities

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