p,p′-DDE depresses the immune competence of chinook salmon (Oncorhynchus tshawytscha) leukocytes

Misumi, Ichiro; Vella, Anthony T.; Leong, Jo‐Ann C.; Nakanishi, Teruyuki; Schreck, Carl B.

doi:10.1016/j.fsi.2004.11.005

Cited by 46 publications

(17 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, as previously shown (Sakai, 1992;Bado-Nilles et al, 2009b), a storage temperature of 4 • C induced low immune destabilization throughout the incubation time. Moreover, at 4 • C, the major impact on the leucocyte immune system was detected at 48 h of incubation along with an important cellular mortality starting from 24 h. In the manner, Misumi et al (2005) showed an important decrease of cellular viability after 17 h especially on splenic leucocytes. As an incubation time of 12-16 h is enough to determine the direct effects of EDCs on cells (Yao et al, 2007;Águila et al, 2013), a maximum incubation time of 12 h at 4 • C was suggesting in order to limit immune destabilization caused by leucocyte death.…”

Section: Discussionmentioning

confidence: 92%

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Bado‐Nilles¹,

Técher²,

Porcher³

et al. 2014

Environmental Toxicology and Pharmacology

View full text Add to dashboard Cite

Today, the list of endocrine disrupting compounds (EDCs) in freshwater and marine environments that mimic or block endogenous hormones is expanding at an alarming rate. As immune and reproductive systems may interact in a bidirectional way, some authors proposed the immune capacities as attractive markers to evaluate the hormonal potential of environmental samples. Thus, the present work proposed to gain more knowledge on direct biological effects of natural and EDCs on female fish splenic leucocyte non-specific immune activities by using ex vivo assays. After determining the optimal required conditions to analyze splenic immune responses, seven different EDCs were tested ex vivo at 0.01, 1 and 100nM over 12h on the leucocyte functions of female three-spined stickleback, Gasterosteus aculeatus. In summary, we found that natural hormones acted as immunostimulants, whilst EDCs were immunosuppressive.

show abstract

Section: Discussionmentioning

confidence: 92%

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Bado‐Nilles¹,

Técher²,

Porcher³

et al. 2014

Environmental Toxicology and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Bioaccumulation of OCPs in biota can lead to some adverse effects on reproduction, nervous systems, and immunity (King et al 2003;Longcore and Stendell 1977;Misumi et al 2005). HMs include potentially toxic elements (arsenic, cadmium, lead and mercury, etc.…”

Section: Introductionmentioning

confidence: 99%

Concentrations, bioaccumulation, and human health risk assessment of organochlorine pesticides and heavy metals in edible fish from Wuhan, China

Cui

Zhu

et al. 2015

Environ Sci Pollut Res

View full text Add to dashboard Cite

The objective of this study was to determine concentration and bioaccumulation of organochlorine pesticides and heavy metals in edible fish from Wuhan, China, in order to assess health risk to the human via fish consumption. Two edible fish species (Aristichthys nobilis and Hypophthalmichthys molitrix) were collected and analyzed for 11 organochlorine pesticides (OCPs) and eight heavy metals (HMs). Concentrations of ∑HCHs, ∑DDTs, and ∑OCPs in fish samples were in the range of 0.37-111.20, not detected (nd)-123.61, and 2.04-189.04 ng g(-1) (wet weight), respectively. Bioaccumulation factors (BAFs) of OCPs in bighead carp (A. nobilis) were higher than those in silver carp (H. molitrix). Concentrations of ∑HMs in bighead carp and silver carp were 352.48 and 345.20 mg kg(-1) (dw), respectively. Daily exposure of OCPs and HMs for consumers was estimated by comparing estimated daily intake (EDI) with different criteria. The results revealed that the EDIs in our study were all lower than those criteria. Target hazard quotient (THQ) and risk ratio (R) were used to evaluate non-carcinogenic and carcinogenic risks, respectively. As regard to non-carcinogenic effects of the contaminants, hazard quotients (THQ) of OCPs and HMs were both lower than 1.0, implying negligible non-carcinogenic risk via fish consumption in study area. Nevertheless, in view of carcinogenic effects of the contaminants, the total value of risk ratio (R) of OCPs was lower than the threshold of tolerable risk while the total value of risk ratio (R) of HMs was higher than the threshold of tolerable risk due to the high carcinogenic risk ratios of As and Cr, indicating high carcinogenic risks via fish consumption. The results demonstrated that HMs in edible fish from Wuhan, China, especially As and Cr required more attention than OCPs.

show abstract

“…Immunological effects of OCs have been reported in studies conducted both in animals [13][14][15][16] and humans [17][18][19][20]. However, previous epidemiological studies on the association between OCs and LRTI have not been able to clearly determine which compound (PCBs, DDE or other OCs) was responsible for these effects due to the high correlation between concentrations of individual compounds [5,6,8].…”

mentioning

confidence: 99%

“…However, some studies have shown an association between DDE exposure levels and the uncontrolled production of cytokines and the increase of nitric oxide production in macrophages, contributing to inflammatory reactions, cytokine imbalance and immune dysregulation [16,17,20]. DDE has also been associated with altered levels and a reduced viability and proliferation capacity of immune system cells (macrophages, lymphocytes and monocytes) [8,17,18], mainly through apoptosis (programmed cell death) [13,30], which seems to be caused by oxidative stress [30]. Although apoptosis plays a very important role under normal physiological conditions, when not regulated, apoptosis can contribute to immune dysregulation and immunodeficiency [31].…”

mentioning

confidence: 99%

Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze

Gascón¹,

Vrijheid²,

Martínez³

et al. 2011

Eur Respir J

View full text Add to dashboard Cite

The aim of our study was to examine whether pre-natal exposure to dichlorodiphenyldichloroethylene (DDE) increases the risk of lower respiratory tract infections (LRTIs) and wheeze in infants.The study is based on a birth cohort of 1,455 mother-child pairs. Maternal serum concentrations of DDE, polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) were measured during pregnancy. Parental reports on LRTI and wheeze were obtained when children were 12-14 months old.35.4% of children developed at least one LRTI episode and 33.6% at least one wheezing episode during their first 12-14 months of life. Median DDE, PCBs and HCB concentrations were 116.3, 113.7 and 46.4 ng?g -1 lipid, respectively. DDE concentrations were associated with LRTI risk (relative risk (RR) per 10% increase 1.11, 95% CI 1.00-1.22), also after adjustment for PCBs and HCB. In all quartiles of DDE exposure, the risk of LRTI was increased compared with the lowest quartile, but the increase was statistically significant only in the third quartile (RR 1.33, 95% CI 1.08-1.62). No association was observed for PCBs and HCB. Results were similar for wheeze. This study suggests that pre-natal DDE exposure is associated with a higher risk of LRTI and wheeze in infants independently of exposure to other organochlorine compounds.

show abstract

p,p′-DDE depresses the immune competence of chinook salmon (Oncorhynchus tshawytscha) leukocytes

Cited by 46 publications

References 52 publications

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.)

Concentrations, bioaccumulation, and human health risk assessment of organochlorine pesticides and heavy metals in edible fish from Wuhan, China

Pre-natal exposure to dichlorodiphenyldichloroethylene and infant lower respiratory tract infections and wheeze

Contact Info

Product

Resources

About