2000
DOI: 10.1097/00001721-200012000-00005
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P-Selectin expression, platelet aggregates, and platelet-derived microparticle formation are increased in peripheral arterial disease

Abstract: Platelet volume has been reported to be increased in vascular disease. Therefore, we studied the relationship of mean platelet volume and platelet count as well as flow cytometrically measured platelet size and platelet function in 50 patients with peripheral arterial disease and 50 healthy volunteers. Platelet activation was measured by P-selectin expression analysis on resting and on stimulated platelets, and the determination of platelet aggregates and platelet-derived microparticles using flow cytometry. P… Show more

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Cited by 91 publications
(67 citation statements)
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“…Platelet microparticles (PMP) are small vesicles that are released from activated platelets. They are encountered in a variety of clinical settings, including arterial thrombosis and peripheral vascular disease [3], hypertension, diabetes, stroke [4][5][6], and ather osclerosis [7]. PMP enhance thrombus formation [8,9] and contribute to platelet activation [10].…”
Section: Introductionmentioning
confidence: 99%
“…Platelet microparticles (PMP) are small vesicles that are released from activated platelets. They are encountered in a variety of clinical settings, including arterial thrombosis and peripheral vascular disease [3], hypertension, diabetes, stroke [4][5][6], and ather osclerosis [7]. PMP enhance thrombus formation [8,9] and contribute to platelet activation [10].…”
Section: Introductionmentioning
confidence: 99%
“…[8][9][10] Elevated numbers of circulating microparticles have been found in patients with a great variety of diseases with vascular involvement and hypercoagulability. [11][12][13][14][15] To the best of our knowledge, there are no reported studies that evaluated circulating microparticles in impotent diabetic men. Therefore, the aims of this study were (a) to evaluate circulating endothelial (EMP) and platelet microparticles (PMP) in diabetic men with ED, (b) to address the relation between circulating microparticles and the severity of ED and (c) to assess the relation between circulating microparticles and endothelial dysfunction.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, the numbers of circulating PMPs reflect the platelet activation status in vivo, for example, in patients with peripheral arterial disease (5 ), unstable angina (6 ), myocardial infarction (MI) (7 ), cerebrovascular accident (8,9 ), and diabetes (9 ). Because analysis of PMPs does not require fixation and can be applied to stored plasma samples, batchwise analysis of the in vivo platelet activation status is feasible.…”
mentioning
confidence: 99%