p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells

Study of phase equilibria and the physicochemical properties of selected pharmaceuticals

“…The action of this drug is similar to ephedrine, therefore it is considered to be a natural substitute. This drugs a natural phenylethylamine derivatives present in some food supplements containing Citrus aurantium, permitted in sport regulations [10]. Therefore, bitter orange extract and its principal protoalkaloidal constituent p-synephrine are widely used in weight loss and weight management.…”

Condensed catechins and their potential health-benefits

“…In skeletal muscle, AMPK acts as a glucose sensor, and promotes insulin-independent glucose uptake (Herman and Kahn, 2006). Some natural compounds that induce AMPK activation in skeletal muscle have been reported, e.g., cyanidin-3-glycoside (Tsuda et al, 2004), mangiferin (Giron et al, 2009), p-synephrine (Hong et al, 2012), berberine (Cheng et al, 2006), and isodihydrocapsiate (Hwang et al, 2008). As shown in Fig.…”

p-Synephrine Suppresses Glucose Production but Not Lipid Accumulation in H4IIE Liver Cells

“…11 In L6 skeletal muscle cells, psynephrine stimulates glucose uptake via AMPK. 8 However, AMPK was not stimulated by p-synephrine in H4IIE liver cells (Fig. 4C).…”

“…Our previous study reported that p-synephrine stimulates glucose uptake in L6 skeletal muscle cells, and that the activation of AMP-activated protein kinase (AMPK) is important in this process. 8 Hepatic glucose production and muscular glucose uptake are two key processes that control plasma glucose levels; therefore, those two processes represent the main targets to treat diabetic hyperglycemia. This study investigated whether p-synephrine alters lipid accumulation and glucose production in H4IIE rat liver cells.…”