2024
DOI: 10.1007/s00401-023-02667-w
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p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003

Lewis W. Taylor,
Elizabeth M. Simzer,
Claire Pimblett
et al.

Abstract: Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to 85 different sites, and there is increasing interest in whether tau phosphorylation at specific epitopes, by specific kinases, plays an important role in disease progression. The AMP-activated protein kinase (AMPK)-related enzyme NUAK1 has been identified as a potential mediator of tau pathology, whereby NUAK1-mediated phosphorylation of tau at Ser356 prevents the… Show more

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Cited by 13 publications
(1 citation statement)
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“…In AD and primary tauopathies PSP and cortico-basal degeneration, MRI studies indicate that tau accumulates in functionally connected brain regions [17][18][19] . Using high-resolution array tomography imaging, we observe phosphorylated tau within synapses 11,20 , and even find pathological tau within synaptic pairs in brain regions affected late in the disease 21,22 , supporting trans-synaptic spread of tau.…”
Section: Introductionmentioning
confidence: 75%
“…In AD and primary tauopathies PSP and cortico-basal degeneration, MRI studies indicate that tau accumulates in functionally connected brain regions [17][18][19] . Using high-resolution array tomography imaging, we observe phosphorylated tau within synapses 11,20 , and even find pathological tau within synaptic pairs in brain regions affected late in the disease 21,22 , supporting trans-synaptic spread of tau.…”
Section: Introductionmentioning
confidence: 75%