P0-2 Spectroscopic Intravascular Photoacoustic Imaging

Sethuraman, Shriram; Wang, B.; Litovsky, Silvio; Amirian, James; Smalling, Richard W.; Emelianov, Stanislav

doi:10.1109/ultsym.2007.299

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In this section, we calculated the slope of the best-fit line at each pixel between the PA signal magnitude and incident laser wavelength. 51,52 The derivative of the PA signal is dependent on the localized optical absorption coefficient of the tissue and thus an indicator of a blood vessel's degree of oxygen saturation.…”

Section: Photoacoustic Spectroscopymentioning

confidence: 99%

3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber

et al. 2011

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Abstract. Understanding the tumor microenvironment is critical to characterizing how cancers operate and predicting their response to treatment. We describe a novel, high-resolution coregistered photoacoustic (PA) and pulse echo (PE) ultrasound system used to image the tumor microenvironment. Compared to traditional optical systems, the platform provides complementary contrast and important depth information. Three mice are implanted with a dorsal skin flap window chamber and injected with PC-3 prostate tumor cells transfected with green fluorescent protein. The ensuing tumor invasion is mapped during three weeks or more using simultaneous PA and PE imaging at 25 MHz, combined with optical and fluorescent techniques. Pulse echo imaging provides details of tumor structure and the surrounding environment with 100-μm 3 resolution. Tumor size increases dramatically with an average volumetric growth rate of 5.35 mm 3 /day, correlating well with 2-D fluorescent imaging (R = 0.97, p < 0.01). Photoacoustic imaging is able to track the underlying vascular network and identify hemorrhaging, while PA spectroscopy helps classify blood vessels according to their optical absorption spectrum, suggesting variation in blood oxygen saturation. Photoacoustic and PE imaging are safe, translational modalities that provide enhanced depth resolution and complementary contrast to track the tumor microenvironment, evaluate new cancer therapies, and develop molecular contrast agents in vivo. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Photoacoustic Spectroscopymentioning

confidence: 99%

3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber

et al. 2011

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Ex Vivo Thermoacoustic Imaging Over Large Fields of View With 108 MHz Irradiation

Eckhart

Balmer

See³

et al. 2011

IEEE Trans. Biomed. Eng.

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Thermoacoustic signals are generated over a large field of view by 900 ns TE10 pulses with 108 MHz carrier frequency. Test specimens selectively absorb the TE10 pulse energy producing rapid thermal expansions that generate ultrasonic pulses. 108 MHz irradiation provides excellent depth penetration in soft tissue, allowing blood and physiologic saline to generate strong signals. Thermoacoustic signal generation from a depth of several cm is well above our systems noise floor. Rotating the test specimen provides single-slice tomographic signal encoding. Filtered back-projection reconstruction yields images over a 6.4 cm field of view. Reconstructions of tissue mimicking prostate phantoms and fresh porcine kidney tissue are presented.

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P0-2 Spectroscopic Intravascular Photoacoustic Imaging

Cited by 2 publications

References 17 publications

3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber

3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber

Ex Vivo Thermoacoustic Imaging Over Large Fields of View With 108 MHz Irradiation

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