P010 5-Aminosalicylates (5-Asas) and Renal Function in Inflammatory Bowel Disease (Ibd): A Systematic Review

Acute Kidney Injury in the Context of Inflammatory Bowel Disease - A Clinical Case

“…Potential 5-ASA-induced TIN may be diagnosed at any interval after beginning treatment. Fifty percent of patients present within the first 12 months, but it has also been observed after several years of treatment initiation [2,4,5]. The exact pathogenic mechanism of AKI is not completely known.…”

Extended-Release Mesalamine Granules for Ulcerative Colitis

“…In a review of 30 studies of mesalamine- or sulfasalazine-containing products that included 2671 patients for over 3000 patient-years of follow-up, the overall rate of nephrotoxicity was 0.26% per patient-year. 21 It is not clear whether mesalamine granules were included in this analysis. Nephrotoxicity with these agents typically presents within the first year of therapy and appears to be idiosyncratic, rather than dose-related.…”

“…Nephrotoxicity with these agents typically presents within the first year of therapy and appears to be idiosyncratic, rather than dose-related. 21 American College of Gastroenterology guidelines suggest that it is reasonable to monitor serum creatinine every 3–6 months during the first year of treatment with mesalamine. 1…”

A Review of Delayed-Release MMX Mesalamine: It's Use in the Treatment of Ulcerative Colitis

“…Prior concerns with regards to nephrotoxicity by salicylates have been laid to rest, after recent studies demonstrated no reduction in glomerular filtration rate during maintenance therapy with mesalamine. 24 There have been case reports of allergic interstitial nephritis which has led to the common practice of periodic monitoring of renal function. 25…”