P02.280 Testosterone, ageing and coital activity

Abstract

Background:Compared to classical neuroleptics amisulpride has been shown to be more effective in treating negative symptoms of schizophrenia. Moreover, it induces only low or negligible extrapyramidal side effects. Concerning this clinical profile it should be regarded as an atypical neuroleptic. !n vitro studies indicate that amisulpride acts selectively at Dz-and Ds-receptors. Concerning its in vitro receptor profile, no significant anti-adrenergic and anticholinergic properties should be expected in vivo.This study 1); prospectively investigated the effects of amisulpride on autonomic neurocardiac function and ECG time relations and 2); reviewed ECG data available from large pre-clinical and clinical studies of amisulpride.