P0396 the Clinical Spectrum of Coeliac Disease in Greek Children - A Single Centre Experience

Karyda, Stavroula; Mouskou, Stella; Avgoustidou, P.; Patsiaura, K.; Koukourgianni, Foteini; Tzimouli, Vassiliki; Kanakoudi, F.

doi:10.1097/00005176-200406001-00520

Cited by 2 publications

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“…Hypochromic microcytic morphology was the most frequent type associated with CD cases in this study , which is concordant with the finding in other studies (14,16,17) . In 43.9% of cases in this study hypochromic microcytic anemia was among the presenting findings leading to the diagnosis of celiac disease, similar result was found in Greek by Karyda et al (26) and in Basrah by Mansoor et al (27) . Whereas higher results were found by Hashim et al (28) , this may be related to the sample selection and time of diagnosis.…”

Section: Discussionsupporting

confidence: 88%

Value of clinical data in diagnosis of symptomatic celiac disease in children

Hafidh¹

2012

Ann Coll Med Mosul

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Objective:To identify the value of clinical data in diagnosis of celiac disease (CD) in children. Patients and methods: a prospective study was conducted in Mosul city during the period from 30 th of October 2007 to 30 th of April 2011. A total of 57 patients (39 males, 18 females) aged more than 6 months on gluten containing diet presented with symptoms suggestive of (CD) were evaluated clinically and serologically using IgA human recombinant tissue transglutaminase antibody. (IgA anti tTG2). Multiple duodenal biopsies were performed for every patient enrolled in this study. CD cases had been followed up 6 months after a gluten free diet (GFD) by weight measurement and the mentioned serological testing. Results: A total of 29 (50.9%) out of 57 symptomatic patients with mean age of 56.1 months, demonstrated positive biopsy results for celiac disease. Failure to thrive (FTT) was noticeable in 25 (86.2%) of studied patients with celiac disease followed by anemia, abdominal distension, offensive stool and chronic diarrhea in decreasing frequency. Catch up of weight was not achieved in 10 (43.5%) out of 23 CD patients with FTT whose (IgA anti tTG2) normalized after 6 months of GFD. Conclusions:The diagnosis of celiac disease on the basis of clinical features alone was incorrect in (49.1%) cases, indicating that diagnosis and lifelong GFD treatment is not justifiable relying on clinical data. Catch up of weight cannot be relied upon as an early marker of clinical improvement in patients with proven adherence to GFD. The result of this study emphasizes the importance of increasing awareness of the accurate tools in diagnosis of CD in children based on serological and biopsy evidences.

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Section: Discussionsupporting

confidence: 88%

Value of clinical data in diagnosis of symptomatic celiac disease in children

Hafidh¹

2012

Ann Coll Med Mosul

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“…La prévalence de la MC dans les séries d'endoscopie varie de 1,8 à 42 % [13][14][15][16][17][18][19][20][21][22]. Les différences sont dues principalement à des critères de sélection diversifiée de patients atteints d'anémie.…”

Section: Discussionunclassified

Intérêt des biopsies duodénales dans l’exploration de l’anémie ferriprive chez le sujet âgé

Chaabane

Youssef

Eljeridi

et al. 2011

J Afr Hepato Gastroenterol

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P0396 the Clinical Spectrum of Coeliac Disease in Greek Children - A Single Centre Experience

Cited by 2 publications

References 2 publications

Value of clinical data in diagnosis of symptomatic celiac disease in children

Value of clinical data in diagnosis of symptomatic celiac disease in children

Intérêt des biopsies duodénales dans l’exploration de l’anémie ferriprive chez le sujet âgé

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