P057 Enhanced expression of CXCL10 in inflammatory bowel disease potential role of mucosal Toll-like receptor 3 stimulation

Østvik, Ann Elisabet; Nilsen, Nadra J.; Granlund, Atle van Beelen; Torp, Sverre Helge; Waldum, Helge L.; Espevik, Terje; Damås, J; Sandvik, Anders

doi:10.1016/s1873-9946(12)60078-6

Cited by 21 publications

(25 citation statements)

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“…This is further supported by the increased expression of CXCR3 (log2 FC: 0.54/0.42, p 0.001/<0.001), a Th1-associated chemokine receptor[33]. Interestingly there was a small increase in expression of the Th2 transcription factor GATA3 in UC (log2 FC: 0.11, p: 0.01), but no increase in IL4 or STAT6 expression, suggesting an IL4/STAT6-independent activation of the Th2-related transcription factor GATA3.…”

Section: Resultsmentioning

confidence: 69%

Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis

et al. 2013

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BackgroundIn inflammatory bowel disease (IBD), genetic susceptibility together with environmental factors disturbs gut homeostasis producing chronic inflammation. The two main IBD subtypes are Ulcerative colitis (UC) and Crohn’s disease (CD). We present the to-date largest microarray gene expression study on IBD encompassing both inflamed and un-inflamed colonic tissue. A meta-analysis including all available, comparable data was used to explore important aspects of IBD inflammation, thereby validating consistent gene expression patterns.MethodsColon pinch biopsies from IBD patients were analysed using Illumina whole genome gene expression technology. Differential expression (DE) was identified using LIMMA linear model in the R statistical computing environment. Results were enriched for gene ontology (GO) categories. Sets of genes encoding antimicrobial proteins (AMP) and proteins involved in T helper (Th) cell differentiation were used in the interpretation of the results. All available data sets were analysed using the same methods, and results were compared on a global and focused level as t-scores.ResultsGene expression in inflamed mucosa from UC and CD are remarkably similar. The meta-analysis confirmed this. The patterns of AMP and Th cell-related gene expression were also very similar, except for IL23A which was consistently higher expressed in UC than in CD. Un-inflamed tissue from patients demonstrated minimal differences from healthy controls.ConclusionsThere is no difference in the Th subgroup involvement between UC and CD. Th1/Th17 related expression, with little Th2 differentiation, dominated both diseases. The different IL23A expression between UC and CD suggests an IBD subtype specific role. AMPs, previously little studied, are strongly overexpressed in IBD. The presented meta-analysis provides a sound background for further research on IBD pathobiology.

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Section: Resultsmentioning

confidence: 69%

Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis

et al. 2013

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“…In the microarray gene expression study on colonic biopsies from IBD patients and healthy controls done previously 6,19 , we now show a significant upregulation of CFB in both active UC and CD vs. non-diseased mucosa and also vs. healthy controls (Fig.3). In active UC …”

Section: Complement Factor B Mrna (Cfb) Expression In Colonic Biopsiesmentioning

confidence: 57%

“…[3][4][5] In previous studies we have focused on TLR3 signaling in colonic epithelial cells in the setting of inflammatory bowel disease. 6,7 TLR3 signaling is interesting as it can be initiated from both viral RNA; either genomic dsRNA or intermediate RNA made during viral replication. Also, there is evidence of TLR3 signaling induced by endogenous RNA.…”

mentioning

confidence: 99%

Mucosal Toll-like Receptor 3-dependent Synthesis of Complement Factor B and Systemic Complement Activation in Inflammatory Bowel Disease

Østvik

Granlund

Gustafsson

et al. 2014

Inflammatory Bowel Diseases

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“…AF increased the intestinal expression of IL1β and IL8 and also of CXCL10 (a chemokine known from intestinal inflammatory disorders) 49 and LPB (LPS binding protein). Cytokines, chemokines, and LBP are known components of AF, even in healthy pregnancies 50 .…”

Section: Discussionmentioning

confidence: 99%

Provision of Amniotic Fluid During Parenteral Nutrition Increases Weight Gain With Limited Effects on Gut Structure, Function, Immunity, and Microbiology in Newborn Preterm Pigs

Østergaard

Shen

Støy

et al. 2015

J Parenter Enteral Nutr

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P057 Enhanced expression of CXCL10 in inflammatory bowel disease potential role of mucosal Toll-like receptor 3 stimulation

Cited by 21 publications

References 0 publications

Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis

Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis

Mucosal Toll-like Receptor 3-dependent Synthesis of Complement Factor B and Systemic Complement Activation in Inflammatory Bowel Disease

Provision of Amniotic Fluid During Parenteral Nutrition Increases Weight Gain With Limited Effects on Gut Structure, Function, Immunity, and Microbiology in Newborn Preterm Pigs

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