2018
DOI: 10.1053/j.gastro.2017.11.106
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P068 Lipid Phosphate Phosphatase-3 (Lpp3) Deficiency Intensifies Intestinal Inflammation in the DSS Model of Ulcerative Colitis: Roles of Lysophosphatidic Acid and Lymphatic/Vascular Networks in Inflammatory Gut Injury?

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“…By the action of lysophopholipaseD, LysoPCs were quickly converted into LysoPA and PA [ 36 ]. We found that PA and LysoPA, which were lipid second messenger, were as well as governor regulator of inflammation [ 37 , 38 ], significantly associated with NAFLD. LysoPE has also been reported to have an effect on the reduction of liver inflammation and the normalization of serum biomarkers in mice with liver disease [ 39 ].…”
Section: Discussionmentioning
confidence: 99%
“…By the action of lysophopholipaseD, LysoPCs were quickly converted into LysoPA and PA [ 36 ]. We found that PA and LysoPA, which were lipid second messenger, were as well as governor regulator of inflammation [ 37 , 38 ], significantly associated with NAFLD. LysoPE has also been reported to have an effect on the reduction of liver inflammation and the normalization of serum biomarkers in mice with liver disease [ 39 ].…”
Section: Discussionmentioning
confidence: 99%