P08.10: The role of Doppler to predict adverse pregnancy outcome in women with pre‐eclampsia

Abstract

was to determine the performance of screening for PE in singleton pregnancies during routine clinical practice. Methods: Between 2011-2012 measurements of UtA-PI were performed at 11-13+6 weeks, and mean pulsatility index (PI) was calculated. Doppler, maternal history and biometry variables (age, ethnic origin, method of conception, BMI, parity, smoking, family or personal history of hypertension or PE, blood pressure) were combined with first trimester PAPP-A to assess the risk of PE. Astraia Software 2.3.2 was used in risk calculation. Results: 2552 women were recruited after informed consent to the study, and outcome data were available in 950 (37.2%) cases. PE occurred in 36 (3.8%) patients. The overall detection rate of early and late PE was 44.4% (16/36) with a false positive rate (FPR) of 12.3% (112/914). There were only 2 cases with early PE, the detection rate was 50% (1/2), with a FPR of 18.7% (178/948). The detection rate of the late PE (delivery at 34 th weeks or after) was 44.1% (15/34), with a FPR of 9.5% (87/914). Conclusions: Combining risk factors in the mother's history with UtA-PI allows calculation of patient-specific risk for the development of PE. Because of the small number of early PE cases in our study population our detection rate can not be taken into consideration. The detection rate (44%) of late PE in our study is comparable with the published retrospective data (60%). The Astraia software used only serum PAPP-A for risk calculation. Further biochemical markers might improve the detection rate. Follow-up of our recruited cases is still going on.