P094. Clinical feasibility of Cerenkov Luminescence Imaging (CLI) for intraoperative assessment of tumour excision margins and sentinel lymph node metastases in breast-conserving surgery

Grootendorst, Maarten; Kothari, Ashutosh; Cariati, Massimiliano; Hamed, Hisham; Douek, Michael; Kovács, Tibor; Cook, Gary; Allen, Sarah; Sibley-Allen, Christopher; Britten, Alan; Pawa, Amit; Nimmo, Fiona; Vyas, Kunal; Tuch, David S.; Pinder, Sarah; Purushotham, Arnie

doi:10.1016/j.ejso.2015.03.132

Cited by 2 publications

(1 citation statement)

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“…The camera provides 8 × 8 cm field of view and 156 µm intrinsic spatial resolution. Interim results show that elevated radiances are detected in cancer compared to normal breast tissue, and that the radiation exposure to surgical staff is low [ 55 , 56 ]. The results from comparing CLI resection margin status and lymph node status to the gold-standard, histopathology, are being prepared for publication at the time of writing.…”

Section: Applications Of CLI For Image-guided Surgery and Ongoing Climentioning

confidence: 99%

Cerenkov luminescence imaging (CLI) for image-guided cancer surgery

Grootendorst

Cariati

Kothari

et al. 2016

Clin Transl Imaging

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Cerenkov luminescence imaging (CLI) is a novel molecular optical imaging technique based on the detection of optical Cerenkov photons emitted by positron emission tomography (PET) imaging agents. The ability to use clinically approved tumour-targeted tracers in combination with small-sized imaging equipment makes CLI a particularly interesting technique for image-guided cancer surgery. The past few years have witnessed a rapid increase in proof-of-concept preclinical studies in this field, and several clinical trials are currently underway. This article provides an overview of the basic principles of Cerenkov radiation and outlines the challenges of CLI-guided surgery for clinical use. The preclinical and clinical trial literature is examined including applications focussed on imageguided lymph node detection and Cerenkov luminescence endoscopy, and the ongoing clinical studies and technological developments are highlighted. By intraoperatively guiding the oncosurgeon towards more accurate and complete resections, CLI has the potential to transform current surgical practice, and improve oncological and cosmetic outcomes for patients.

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Section: Applications Of CLI For Image-guided Surgery and Ongoing Climentioning

confidence: 99%