P1.01-015 Polyphenols-Rich Fruit Extracts Prevent Tobacco Specific Nitrosamine-Induced DNA Damage in Lung Epithelial Cells

Abstract

was 32 years and the latency of lung cancer was 50 years. For Goddard score of emphysematous changes, 28% showed 0 point and 33% of 1w4 points and more than 21 points occupied only 4%, which means very low percentages of emphysematous changes for these asbestos-related lung cancer, nonetheless of high percentages of heavy smokers. For pulmonary function test, FEV1.0% is 70.5%±11.3% and % FEV1.0 is 85.6±22.2%. More than half patients are normal pulmonary function except more than 1,000 of Brinkman index or more than 15 points of Goddard score. From the classification of GOLD criteria, 54.1% are normal, stage 1 is 20.7%, stage 2 is 22.5 % stage 3 is 1.8% and stage 4 is only 0.9%. Conclusion:Almost all of asbestos-related lung cancer in Japan are heavy smoker, but 61% showed none or low grade of emphysematous changes by chest CT and only 2.7% had severe pulmonary dysfunction.