P1-01-05: Conditioning by the Tumor Environment Turns Invariant Natural Killer T Cells into Negative Regulators of Anti-Tumor Immunity Elicited by Treatment.
Abstract:Background: Local suppression in the tumor microenvironment remains an important obstacle to success of immune-based therapy. We have previously shown in the 4T1 model of metastatic breast cancer that combination radiotherapy (RT) to the primary tumor and CTLA-4 blockade can elicit a robust anti-tumor effector response that can inhibit metastases and prolong survival. However, complete cure and long-term memory was seen in only a small fraction of mice, prompting us to investigate new ways to improve the respo… Show more
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