P1.03-33 Analysis of Lipid Metabolism Genes in Advanced Small Cell Lung Cancer

Merino, M.; Fernández, Lilia; Moyano, M. Sereno; Molina, Ana Ramı́rez de; Rubio, Judit; Colmenarejo, Gonzalo; Raposo, César Gómez; Gómez, Miriam López; Martínez, Sandra Falagán; Zamora, Cristina Aguayo; Tévar, Francisco Zambrana; Gordo, A.M. Jiménez; Sáez, Elena

doi:10.1016/j.jtho.2019.08.885

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“…30 Since lung cancer is the leading cause of cancer-related death among both men and women, more and more research is focusing on the role of lipid metabolism in lung cancer. [42][43][44][45] Increasing evidence suggests that disordered lipid metabolism is important when evaluating tumor stage and metastasis, determining the effectiveness of treatment, and developing new therapeutic targets and disease-specific biomarkers. [46][47][48] Various biological samples including tissues, surgical aerosols, and sera have been used in studies on lipid metabolism in lung cancer.…”

Section: Lipids Profile Research and Surgical Margin Assessment In Hu...mentioning

confidence: 99%

Roles of Lipid Profiles in Human Non-Small Cell Lung Cancer

Zhang

Huang

Tang

et al. 2021

Technol Cancer Res Treat

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Aims: This review aims to identify lipid biomarkers of non-small cell lung cancer (NSCLC) in human tissue samples and discuss the roles of lipids in tissue molecular identification, the discovery of potential biomarkers, and surgical margin assessment. Methods: A review of the literature focused on lipid-related research using mass spectrometry (MS) techniques in human NSCLC tissues from January 1, 2015, to November 20, 2020, was conducted. The quality of included studies was assessed using the QUADAS-2 tool. Results: Twelve studies met the inclusion criteria and were included in the review. The risk of bias was unclear in the majority of the studies. The contents of lipids including fatty acids, phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, cardiolipin, phosphatidyl serine, phosphatidyl glycerol, ceramide, lysophosphatidylethanolamine, lysophosphatidylcholine, and lysophosphatidylglycerol differed significantly between cancer and healthy tissues. The sensitivity or specificity of the discrimination model was reported in 8 studies, and the sensitivity and specificity varied among the reported methods. The lipid profiles differed between adenocarcinoma and squamous cell carcinoma NSCLC subtypes. Conclusion: In preclinical studies, MS analysis and multiple discrimination models can be combined to distinguish NSCLC tissues from healthy tissues based on lipid profiles, which provides a new opportunity to evaluate the surgical margin and cancer subtype intraoperatively. Future studies should provide guidance for selecting patients and discrimination models to develop an improved method for clinical application.

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