P1‐034: Dietary DHA supplementation leads to synaptic protection and cognitive preservation in an Alzheimer's disease mouse model

Oster, Thierry; Florent-Béchard, Sabrina; Allouche, Ahmad; Garcia, Pierre; Malaplate-Armand, Catherine; Kriem, Badreddine; Stenger, Christophe; Youssef, Ihsen; Desbène, Cédric; Hanse, Marine; Koziel, Violette; Escanyé, Marie-Christine; Pratte, Dagmar; Yen-Potin, Frances; Olivier, Jean‐Luc; Pillot, Thierry

doi:10.1016/j.jalz.2009.04.037

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“…Both parameters were strongly correlated with learning as well as memory capacities and were implicated in the prevention of Aβ oligomer-induced impairments. Therefore, DHA is important in AD prevention ( 39 ). DHA was shown to protect against and ameliorate learning ability impairments in Aβ1–40 infused AD rat models, with concurrent increases in DHA levels and decreases in lipid peroxide levels and reactive oxygen species in the cortico-hippocampal tissues ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

DHA Ameliorates Cognitive Ability, Reduces Amyloid Deposition, and Nerve Fiber Production in Alzheimer’s Disease

Xiao

Xiang²,

Chen

et al. 2022

Front. Nutr.

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BackgroundThe etiology of Alzheimer’s disease (AD) is very complex. Docosahexaenoic acid (DHA) is important in cognitive ability and nervous system development. A limited number of studies have evaluated the efficacy of DHA in the treatment of AD.IntroductionWe detected neurofibrillary tangles (NFT) in the hippocampus and cortex of transgenic mice brain through silver glycine staining. We determined the activity of neurons by staining Nissl bodies, used liquid NMR to detect metabolites in the brain, and functional magnetic resonance imaging results to observe the connection signal value between brain regions.Materials and MethodsWe fed 3-month-old APP/PS1 double transgenic mice with DHA mixed feeds for 4 months to assess the effects of DHA on cognitive ability in AD mice through the Morris water maze and open field tests. To evaluate its effects with AD pathology, continuous feeding was done until the mice reached 9 months of age.ResultsCompared to AD mice, escape latency significantly decreased on the fifth day while swimming speed, target quadrant stay time, and the crossing number of platforms increased by varying degrees after DHA treatment. Brain tissue section staining revealed that DHA significantly reduced Aβ and nerve fibers in the brain of AD mice.ConclusionDHA significantly reduced the deposition of Aβ in the brain and inhibited the production of nerve fibers, thereby increasing cognitive abilities in AD mice. In addition, DHA suppressed blood lipid levels, and restored uric acid and urea levels, implying that DHA is a potential therapeutic option for early AD.

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Section: Discussionmentioning

confidence: 99%