P1.07 Rosuvastatin Increases Extracellular Adenosine in Humans in Vivo: A New Perspective on Cardiovascular Protection

How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

“…Only recently, Haskó and co-workers (21) demonstrated that ecto-5NT decreases mortality and organ injury during murine sepsis. Interestingly, recent studies in animals and in humans in vivo have shown that statins cause an activation of ecto-5NT activity (14,22,23). Furthermore, it was recently demonstrated that the use of statins during intensive care unit stay reduces hospital mortality (24), but whether an increase in extracellular adenosine accounts for the survival benefit needs to be further explored.…”

Prevention of Peri-procedural Myocardial Injury Using a Single High Loading Dose of Rosuvastatin

“…In addition, in a forearm model of ischemia-reperfusion injury rosuvastatin administration has been shown to significantly increase the vasodilator response to dipyridamole by the mechanism of increased extracellular adenosine [23].…”

Short-term Statin Treatment Does Not Prevent Ischemia and Reperfusion-induced Endothelial Dysfunction in Humans

“…[13][14][15][16] Indeed, we have recently demonstrated that rosuvastatin reduces IR-induced phosphatidylserine exposition in the thenar muscle in humans in vivo, involving activation of adenosine receptors. 17 In addition, we have reported that rosuvastatin improves formation of adenosine in the forearm and increases forearm postocclusive hyperemia via an adenosine-dependent mechanism. Finally, we have shown in humans a 50% increase in ecto-59-nucleotidase activity on peripheral blood mononuclear cells after rosuvastatin treatment as compared with placebo.…”