P1–151: Cross‐sectional clinical, neuropsychological, neuroimaging, neurophysiological and biochemical characterization of people with mild cognitive impairment in WP5 pharmacog/E‐ADNI study

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

“…about 12–24 months) in groups of aMCI subjects and ADD patients (see for a review [348]): 1) increased delta-theta and increased alpha-beta power density at parieto-occipital electrodes [349]; 2) increased theta power density, decreased beta power density, and decreased mean frequency at the temporal and temporo-occipital electrodes [316, 350, 351]; 3) increased delta and increased alpha 1 in parieto-occipital sources [352, 353]; and 4) reduced cortical connectivity as revealed by graph theory indexes [347]. …”

“…enhancing the cholinergic tone) showed beneficial or protective effects in delta [320, 354–356], theta [321, 356, 357], and alpha rhythms [355, 358]. When observed at short-term, these effects predicted longer-term therapy efficacy [357, 359, 360](for a review see [352]). However, some contradictory findings suggest future more controlled cross-validation studies [361, 362].…”

“…Abnormal posterior cortical delta rhythms in ADD patients might reflect an upregulation of their generation mechanisms in quiet wakefulness, possibly due to cortical blood hypoperfusion and synaptic dysfunction in the same regions [363–366] and atrophy in the posterior cortex [312, 352, 367–369]. Furthermore, reduced posterior cortical alpha rhythms in ADD subjects might be due to an unselective tonic cortical excitation in populations of cortical pyramidal, thalamo-cortical, and reticular thalamic neurons generating those rhythms [370–372].…”