P1‐195: Involvement of the choroid plexus in the clearance of Aβ

Giannoni, Patrizia; McIntee, Farron; Gandy, Samuel E.; Rostagno, Agueda; Ghiso, Jorge

doi:10.1016/j.jalz.2010.05.745

Cited by 1 publication

(1 citation statement)

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“…There is a preclinical period covering several years in both AD and other dementias, called MCI, during which early and mild cognitive deficits can be identified (Brand et al, 2003; Galluzzi and Frisoni, 2008; Bordet et al, 2010). On average 50% of the individuals with MCI will develop AD within a few years (Trojanowski et al, 2010). Cognitive decline in early stages of AD typically begins with deficits in episodic memory (Bäckman et al, 2004; Ringman, 2005; Sarazin and Dubois, 2005; Thomas-Anterion and Laurent, 2006; Bäckman and Small, 2007; Dubois et al, 2007; Small and Bäckman, 2007; Schwindt and Black, 2009).…”

Section: Impairments Of Human Episodic Memorymentioning

confidence: 99%

Perspectives on Episodic-Like and Episodic Memory

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Zlomuzica

Kinugawa

et al. 2013

Front. Behav. Neurosci.

100

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Episodic memory refers to the conscious recollection of a personal experience that contains information on what has happened and also where and when it happened. Recollection from episodic memory also implies a kind of first-person subjectivity that has been termed autonoetic consciousness. Episodic memory is extremely sensitive to cerebral aging and neurodegenerative diseases. In Alzheimer’s disease deficits in episodic memory function are among the first cognitive symptoms observed. Furthermore, impaired episodic memory function is also observed in a variety of other neuropsychiatric diseases including dissociative disorders, schizophrenia, and Parkinson disease. Unfortunately, it is quite difficult to induce and measure episodic memories in the laboratory and it is even more difficult to measure it in clinical populations. Presently, the tests used to assess episodic memory function do not comply with even down-sized definitions of episodic-like memory as a memory for what happened, where, and when. They also require sophisticated verbal competences and are difficult to apply to patient populations. In this review, we will summarize the progress made in defining behavioral criteria of episodic-like memory in animals (and humans) as well as the perspectives in developing novel tests of human episodic memory which can also account for phenomenological aspects of episodic memory such as autonoetic awareness. We will also define basic behavioral, procedural, and phenomenological criteria which might be helpful for the development of a valid and reliable clinical test of human episodic memory.

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