P1.32: Primary Lung Cancer Presenting as Pneumothorax

Gradica, Fadil; Gradica, Flora; Rexha, V.; Lisha, Lutfi; Gradica, Sali; Argjiri, Dhimitraq; Cani, Alma; Lala, D.; Pere, A.; Selimi, Elez

doi:10.1016/j.jtho.2016.08.054

Cited by 3 publications

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“…▪ Langerhans-Zell-Granulomatose [23] ▪ Lymphangioleiomyomatose (LAM) [24] ▪ Birt-Hogg-Dubé-Syndrom [25,26] Sarkoidose [27] maligne Erkrankungen Lungenkarzinom [7,28] sekundäre maligne Neoplasien der Lunge [ diese Fälle eher einem Therapieversagen als Rezidiven zugeordnet werden sollten.…”

Section: Iatrogener Pneumothoraxunclassified

Management of Spontaneous Pneumothorax and Postinterventional Pneumothorax: German S3-Guideline

et al. 2018

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Section: Iatrogener Pneumothoraxunclassified

Management of Spontaneous Pneumothorax and Postinterventional Pneumothorax: German S3-Guideline

et al. 2018

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“…Several hypotheses have been taken into account to explain the pathogenesis of pneumothorax secondary to malignant disease, which include (i) an alteration of the pleural surface following tumoral pleural infiltration; (ii) rupture of a necrotic tumoral nodule; and (iii) necrosis of subpleural metastases [27].…”

Section: Pathophysiologymentioning

confidence: 99%

Secondary Pneumothorax from a Surgical Perspective

Sobrero¹,

Leo²,

Sandri³

2022

Pleura - A Surgical Perspective

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Although less frequent than the primary spontaneous pneumothorax (PSP), secondary pneumothoraces (SP) are a common clinical problem with a wide range of severity, depending on the triggering cause(s) and patient clinical condition. By definition, an SP occurs in those patients with an underlying condition that alters the normal lung parenchyma and/or the visceral pleura and determines air entry in the pleural space (e.g., COPD) or, eventually, following trauma or invasive procedures (i.e., iatrogenic pneumothorax). Less frequent, yet described, is SP occurring in neoplastic patients or infectious ones. The gravity of an SP is directly correlated to the underlying cause and patients’ clinical conditions. For example, it may be a life-threatening condition in an end-stage COPD but less severe in a catamenial related syndrome. In this chapter, we are providing a surgical overview of the most relevant and updated information on etiology, incidence, pathophysiology, and management of secondary pneumothoraces.

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Management of Spontaneous Pneumothorax and Post-Interventional Pneumothorax: German S3 Guideline

et al. 2018

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In Germany, 10,000 cases of spontaneous pneumothorax are treated inpatient every year. The German Society for Thoracic Surgery, in co-operation with the German Society for Pulmonology, the German Radiological Society, and the German Society of Internal Medicine has developed an S3 guideline on spontaneous pneumothorax and post-interventional pneumothorax moderated by the German Association of Scientific Medical Societies. Method: Based on the source guideline of the British Thoracic Society (2010) for spontaneous pneumothorax, a literature search on spontaneous pneumothorax was carried out from 2008 onwards, for post-interventional pneumothorax from 1960 onwards. Evidence levels according to the Oxford Center for Evidence-Based Medicine (2011) were assigned to the relevant studies found. Recommendations according to grade (A: “we recommend”/“we do not recommend,” B: “we suggest”/“we do not suggest”) were determined in 3 consensus conferences by the nominal group process. Results: The algorithms for primary and secondary pneumothorax differ in the indication for CT scan as well as in the indication for chest drainage application and video-assisted thoracic surgery. Indication for surgery is recommended individually taking into account the risk of recurrence, life circumstances, patient preferences, and procedure risks. For some forms of secondary pneumothorax, a reserved indication for surgery is recommended. Therapy of post-interventional spontaneous pneumothorax is similar to that of primary spontaneous pneumothorax. Discussion: The recommendations of the S3 Guideline provide assistance in managing spontaneous pneumothorax and post-interventional pneumothorax. Whether this will affect existing deviant diagnostic and therapeutic measures will be demonstrated by future epidemiological studies.

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P1.32: Primary Lung Cancer Presenting as Pneumothorax

Abstract: Background: Afatinib, an irreversible ErbB family blocker, significantly improved progression-free survival (PFS) versus platinum-doublet chemotherapy as first-

Cited by 3 publications

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Management of Spontaneous Pneumothorax and Postinterventional Pneumothorax: German S3-Guideline

Management of Spontaneous Pneumothorax and Postinterventional Pneumothorax: German S3-Guideline

Secondary Pneumothorax from a Surgical Perspective

Management of Spontaneous Pneumothorax and Post-Interventional Pneumothorax: German S3 Guideline

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