P1‐369: Transcranial Magnetic Stimulation of Deep Brain Regions in Alzheimer's Disease

Ash, Elissa; Bregman, Noa; Moore, Orna; Korczyn, Amos D.; Zangen, A.

doi:10.1016/j.jalz.2014.05.611

Cited by 4 publications

(10 citation statements)

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“…Turriziani et al () used low‐frequency rTMS (1 Hz), and two other studies involved low‐frequency rTMS (Ahmed et al , ; Ash et al , ). All the other studies applied high‐frequency pulses (10 or 20 Hz).…”

Section: Resultsmentioning

confidence: 99%

“…Transcranial magnetic stimulation parameters. Most studies used a figure-of-eight coil, one study used an H-coil (Coppi et al, 2015) and three studies did not report which type of coil was used (Ash et al, 2014;Rutherford et al, 2015;Lee et al, 2016). All studies involved the frontal/prefrontal region as the TMS target sites: seven studies used the DLPFC as the sole target (either unilaterally or bilaterally) (Cotelli et al, 2008;Cotelli et al, 2011;Ahmed et al, 2012;Turriziani et al, 2012;Drumond Marra et al, 2015;Rutherford et al, 2015;Wu et al, 2015); three studies targeted the same combination of sites involving Broca's area, Wernicke's area, the DLPFC and the parietal cortex (Brem et al, 2013;Rabey et al, 2013;Lee et al, 2016).…”

Section: Description Of Studiesmentioning

confidence: 99%

“…All studies involved the frontal/prefrontal region as the TMS target sites: seven studies used the DLPFC as the sole target (either unilaterally or bilaterally) (Cotelli et al, 2008;Cotelli et al, 2011;Ahmed et al, 2012;Turriziani et al, 2012;Drumond Marra et al, 2015;Rutherford et al, 2015;Wu et al, 2015); three studies targeted the same combination of sites involving Broca's area, Wernicke's area, the DLPFC and the parietal cortex (Brem et al, 2013;Rabey et al, 2013;Lee et al, 2016). Coppi et al (2015) and Ash et al (2014) reported using the frontoparietal-temporal lobes and prefrontal areas, respectively, without specifying the exact target site.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…Regarding the targeting method, six studies used magnetic resonance imaging-guided navigation (Cotelli et al, 2008;Cotelli et al, 2011;Turriziani et al, 2012;Rabey et al, 2013;Anderkova et al, 2015;Lee et al, 2016) and three studies used a non-imaging-based technique (Ahmed et al, 2012;Drumond Marra et al, 2015;Rutherford et al, 2015), either a 5-cm rule to locate the DLPFC (Pascual-Leone et al , 1996) or an electroencephalography 10-20 system to locate the brain area. Turriziani et al (2012) used low-frequency rTMS (1 Hz), and two other studies involved lowfrequency rTMS (Ahmed et al, 2012;Ash et al, 2014). All the other studies applied high-frequency pulses (10 or 20 Hz).…”

Section: Description Of Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis

Cheng

Wong

Lee

et al. 2017

Int J Geriat Psychiatry

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Objective: This systematic review and meta-analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment. Methods: A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini-Mental State Examination or the Alzheimer's Disease Assessment Scale-cognitive subscale. Results: Seven RCTs were included in the meta-analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84). Conclusions: High-frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well-tolerated alternative intervention for cognition.

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Section: Resultsmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis

Cheng

Wong

Lee

et al. 2017

Int J Geriat Psychiatry

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“…These findings present evidence that TMS may be helpful in restoring brain functions and could reflect rTMS potential to recruit compensatory networks that underlie memory-encoding and other cognitive processes [69]. We have performed rTMS of deep prefrontal brain regions in patients with mild to moderate AD and found modest but significant improvements in multiple cognitive measures, including global cognitive score on the NeuroTrax™ moderate to severe battery (NeuroTrax Corp., Bellaire, TX), and on language and executive functioning subscores of the ADAS-cog [70].…”

Section: Tms Studies Investigating Pathophysiologic Brain Changes In Admentioning

confidence: 99%

TMS as a Tool for Examining Cognitive Processing

Nevler

Ash

2015

Curr Neurol Neurosci Rep

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Transcranial magnetic stimulation (TMS) is a non-invasive method where an externally placed, rapidly changing magnetic field causes induction of weak electric currents that lead to changes in neuronal polarization and activity. TMS is a modality that has emerged as a unique tool in the study of functional neuroscience for several reasons. TMS can be used to selectively activate or inhibit specific cortical structures, leading to transient perturbations in their function. Systematic study of these perturbations has been employed to determine the function of specific cortical structures and to investigate structure-function relationships. These studies extend to the functional mapping of brain structures as well as brain networks. While TMS was first validated in studies of motor cortex function, it has been applied to the study of cognition and cognitive processing. "Virtual lesions" can be transiently induced in areas of eloquent cortex that allow for the evaluation of their function in cognition and behavior and can be used to evaluate the modes and hierarchy of control of these functions. When TMS is delivered in a repetitive fashion, long-term alterations of cortical function are induced which can be used to study functional brain plasticity, and the changes in brain plasticity in different cognitive states, including aging and diseases involving cognition. Furthermore, repetitive TMS strategies have been developed as possible modulators of cognitive function, with potential to serve as cognitive enhancers in both healthy and disease states. In this review, specific attention is given to the use of TMS in the evaluation of neurophysiologic changes in Alzheimer's disease (AD), as well as the potential role of TMS as a cognitive enhancing therapy in AD.

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