P1-97 Demographic analysis of osteosarcoma and ewing sarcoma family of tumours in 0-49 year olds in Great Britain, 1980-2005: a small-area approach

Abstract

Introduction Primary bone cancers (PBC) occur most often in young people. Osteosarcoma and Ewing sarcoma family of bone tumours (ESFT) are the most common sub-groups but aetiology remains unclear. Some childhood cancer rates are known to vary with socioeconomic status. Therefore, this study examined geographical patterning in osteosarcoma and ESFT incidence, diagnosed in 0e49 year olds in Great Britain (GB) during 1980e2005. The analysis focussed on putative associations with area characteristics including deprivation and population density (PD). Methods Data were obtained from all regional cancer registries in GB. Negative binomial regression was used to examine the relationship between incidence rates with PD and Townsend deprivation score (TDS). These models were fitted to small-area census data aggregated by three age bands (0e14, 15e29 and 30e49 years) and gender with the logarithm of the 'at-risk' population as an offset. Results There were 2566 osteosarcoma cases and 1650 ESFT cases. After adjustment for age and gender osteosarcoma incidence demonstrated a negative association with TDS (RR for one unit increase in deprivation level ¼0.975; 95% CI 0.963 to 0.986). ESFT incidence showed a negative association with PD (RR for increase of one person/ hectare ¼0.981; 95% CI 0.972 to 0.989) and non-car ownership (RR for 1% increase of non-car ownership ¼0.996; 95% CI 0.993 to 1.000). Conclusion More deprived areas have lower osteosarcoma incidence. Higher ESFT incidence is associated with lower PD and higher car ownership levels. Both factors are rural area characteristics. Further study of environmental exposures or land use is recommended. Introduction Brazilian families' expenditure with health achieves high proportion of their incomes, especially to purchase medicines. The aim of this study was to investigate the associated factors with the proportion of income spent to purchase medicines in adults from 20 to 59 years of age. Methods A cross sectional population-based study (n¼1720) was carried out in Florianópolis, Brazil, 2009. Commitment of 10% or more of family income (C10) with medicines expenditure (yes/no) was considered the outcome. Gender, age, skin colour, schooling, per capita family income, self-reported chronic diseases, hospitalisation in the last year, family health program coverage, and self-rated health were the exploratory variables. Crude and adjusted prevalence ratios (PR) were obtained through Poisson regression analyses. P1-98 INEQUALITIES IN MEDICINES EXPENDITURE AMONG ADULTS: A POPULATION-BASED STUDY IN SOUTH OF BRAZILResults The prevalence of the C10 was 12.2% (95% CI 10.4 to 13.9) and it was higher among women (PR 1.59, 95% CI 1.16 to 2.18),