P1045 Clinico-epidemiologic feature and outcome analysis of Crimean-Congo haemorraghic fever in Iran (1999–2006)

Mardani, Masoud; Goya, Mohammad Mahdi; Zainali, Mohammad; Jahromi, Maryam Keshtkar

doi:10.1016/s0924-8579(07)70886-5

Cited by 3 publications

(3 citation statements)

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“…Outbreaks have been documented in all these areas since the 1960 s, with the most recent cases coming from Iran [13] and Turkey [14]. In addition, climatic, environmental and agricultural changes may affect the distribution of the tick vector and influence the location and timing of outbreaks.…”

Section: Introductionmentioning

confidence: 99%

“…One of the most important features of the virus is its diverse geographic distribution including Africa, Asia, Eastern Europe and the Middle East [ 12 ], making it the most widespread tick-borne virus infecting humans. Outbreaks have been documented in all these areas since the 1960 s, with the most recent cases coming from Iran [ 13 ] and Turkey [ 14 ]. In addition, climatic, environmental and agricultural changes may affect the distribution of the tick vector and influence the location and timing of outbreaks.…”

Section: Introductionmentioning

confidence: 99%

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Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis

Soares‐Weiser

Thomas

Thomson³

et al. 2010

BMC Infect Dis

103

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BackgroundCrimean-Congo hemorrhagic fever epidemics often occur in areas where health services are limited, and result in high case fatality rates. Besides intensive care, ribavirin is often recommended. A solid evidence base for the use of this drug will help justify assuring access to the drug in areas where epidemics are common.MethodsWe carried out a systematic review of observational and experimental studies of people with suspected or confirmed Crimean-Congo hemorrhagic fever that included comparisons between patients given ribavirin and those not. We extracted data on mortality, hospital stay, and adverse events. Risk of bias was assessed using a standard checklist, and data were presented in meta-analytical graphs, stratified by study design, and GRADE tables presented. The risk of bias was summarised using the GRADE method.Results21 unique studies, including one randomised controlled trial of ribavirin, were included. Quality of the evidence was very low, with a Down and Black median score of 4 (maximum possible 33). Ribavirin treatment was not shown to be superior to no ribavirin treatment for mortality rate in a single RCT (RR: 1.13, 95%CI: 0.29 to 4.32, 136 participants, GRADE=low quality evidence); but ribavirin was associated with reduced mortality by 44% when compared to no ribavirin treatment in the pooled observational studies (RR: 0.56, 95%CI: 0.35 to 0.90, 955 participants; GRADE=very low quality evidence). Adverse events were more common with the ribavirin patients, but no severe adverse events were reported. No difference in length of hospital stay was reported.ConclusionsNo clear message of benefit is available from the current data on ribavirin as observational data are heavily confounded, and the one trial carried out has limited power. However, ribavirin could potentially have benefits in this condition and these results clearly indicate a pragmatic, randomised controlled trial in the context of good quality supportive care, is urgently needed and ethically justified.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis

Soares‐Weiser

Thomas

Thomson³

et al. 2010

BMC Infect Dis

103

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“…The virus is distributed in Asia, the Middle East, Eastern Europe and Africa 10. Several outbreaks have been reported in Iran11 and Turkey 12…”

Section: Discussionmentioning

confidence: 99%

Crimean-Congo haemorrhagic fever presenting with acute compartment syndrome of the extremities (think beyond normal infections)

et al. 2020

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Crimean-Congo haemorrhagic fever (CCHF) is a viral zoonosis transmitted to humans and animals (which act as a reservoir) through the bite of a ‘Hyalomma’ tick. CCHF virus belongs to the genus Nairovirus. Humans are infected when they come in direct contact with the blood or secretions of infected livestock or other infected humans. This disease initially presents with non-specific febrile symptoms common to many viral illnesses and later progresses to disseminated intravascular coagulation (DIC) with haemorrhagic manifestations.We present the case of a middle-aged man with CCHF. He presented to the hospital with DIC and acute compartment syndrome in the right forearm, requiring urgent orthopaedic intervention. The diagnosis was delayed because there was no clear history of contact. The patient was started taking ribavirin on the fifth day of hospital admission. He recovered fully.

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DNA ligase photocrosslinked cryogenic column based biotinylation kit for viral hybridization and detection

Köse

Öziç

Yılmaz

et al. 2019

Process Biochemistry

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P1045 Clinico-epidemiologic feature and outcome analysis of Crimean-Congo haemorraghic fever in Iran (1999–2006)

Cited by 3 publications

References 0 publications

Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis

Ribavirin for Crimean-Congo hemorrhagic fever: systematic review and meta-analysis

Crimean-Congo haemorrhagic fever presenting with acute compartment syndrome of the extremities (think beyond normal infections)

DNA ligase photocrosslinked cryogenic column based biotinylation kit for viral hybridization and detection

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