P126. A Comparison of the Clinical Wound Healing Outcomes of Autologous Skin Grafts and Tissue-Engineered Skin Constructs: A Systematic Review and Meta-Analysis

Abstract

PRS Global Open • 2022 flaps. 30-day mortality following reconstruction was 3.9%. Median length-of-stay after initial debridement was 8 days (IQR5-15). Of patients with flaps, 54 (48%) required multiple debridements prior to closure, and 30 (27%) underwent reoperation after flap closure. Patients who needed only a single debridement were significantly less likely to have a complication requiring reoperation (N= 10/58 vs 20/54, 17% vs 37%, p=0.02), undergo a second flap (N=6/58 vs 17/54, 10% vs 32%, p<0.001) or, if plated, require removal of sternal plates (N=6/58 vs 11/22, 18% vs 50%, p=0.02). CONCLUSION:Although sternal dehiscence remains a complex challenge, an aggressive treatment algorithm, including debridement, flap closure and consideration of RSF, can achieve good long-term outcomes. In appropriately selected patients, RSF does not appear to increase the risk of reoperation. We hypothesize that earlier surgical intervention, before the development of systemic symptoms, may be associated with improved outcomes.

Acellular fish skin grafts in the treatment of diabetic wounds: Advantages and clinical translation

“…Many studies have shown that skin transplantation has a significant improvement in the treatment of diabetic wounds. [10][11][12] Skin transplantation can be divided into homotransplantation and xenotransplantation according to the source of substitutes. Autologous transplantation needs to create new wounds in different parts of the patient's own body.…”

“…In the past, collagen dressings and silver sulfadiazine cream commonly used in clinical practice need to be replaced frequently, which is likely to cause secondary damage to the wound surface of patients and cause some trouble to health care providers 9 (Figure 1). Many studies have shown that skin transplantation has a significant improvement in the treatment of diabetic wounds 10–12 . Skin transplantation can be divided into homotransplantation and xenotransplantation according to the source of substitutes.…”