P137Prognostic value of cardiac magnetic resonance in systemic sclerosis

Pepe, Alessia; Meloni, Antonella; Bruni, Cosimo; Marchi, Daniele De; Todiere, Giancarlo; Fulgenzi, Fabio; Ghebru, Yacob; Guiducci, Serena; Caterina, R De; Cerinic, M Matucci; Gargani, Luna

doi:10.1093/ehjci/jez117

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“…According to the modified Lake Louise criteria for inflammatory cardiomyopathies [25], a diagnosis of active acute myocarditis may be made with considerable confidence if at least one T2-based criterion (global or regional increase of myocardial T2 relaxation time or an increased signal intensity in T2-weighted CMR images) and at least one T1-based criterion (increased myocardial T1, extracellular volume, or late gadolinium enhancement) are diagnostically pathologic. At the time of writing, there are only two studies demonstrating that LGE presence on CMR (a T1-based criterion) and especially a diffuse subendocardial fibrosis pattern at baseline carries an ominous prognosis in SSc patients [21,26]. Our results are also in agreement with these studies and patients with diffuse subendocardial fibrosis from our patient cohort indeed also experienced rapid evolution to HF at follow-up.…”

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confidence: 91%

Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value

et al. 2019

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Background: Acute cardiac events are a significant contributor to mortality in systemic sclerosis (SSc). However, echocardiographic evaluation may be deceptively normal during an acute presentation. We hypothesized that in diffuse SSc patients presenting with acute cardiac events and a normal echocardiogram, cardiovascular magnetic resonance (CMR) would have incremental diagnostic/prognostic value. Methods. 50 consecutive diffuse SSc patients with normal echocardiograms were evaluated using a 1.5T system. A total of 27 (63%) had experienced an acute cardiac event three to tendays before CMR evaluation (rhythm disturbances, angina pectoris, shortness of breath). Left/right ventricular (LV/RV) volumes and ejection fractions (EF), as well as LV mass, the T2-signal ratio, early/late gadolinium enhancement (EGE/LGE), native/post-contrast T1-mapping, T2-mapping and extracellular volume fraction (ECV) were compared between the event and no-event groups. Results: No differences were identified in LV/RV volumes/EF/mass. In logistic regression analyses, independent predictors of belonging to the event group were EGE (odds ratio (95% CI): 1.55 (1.06-2.26), p = 0.024), LGE (1.81 (1.23-2.67), p = 0.003), T2 mapping (1.20 (1.06-1.36), p = 0.004) and native/post-contrast T1 mapping (1.17 (1.04-1.32), p = 0.007 and 0.86 (0.75-0.98), p = 0.025). At a median follow-up of~1.2 years, 42% vs. 11% of the event/no-event group respectively reached a combined endpoint of event occurrence/recurrence or cardiovascular mortality. Of the independent predictors resulting from logistic regression analyses, only LGE (hazard ratio (95% CI): 1.20 (1.11-1.30), p < 0.001), T2-mapping (1.07 (1.01-1.14), p = 0.025) and native T1-mapping (1.08 (1.01-1.15), p = 0.017) independently predicted the combined endpoint. Conclusions: A normal echocardiogram does not preclude myocardial lesions in diffuse SSc patients, which can be detected by CMR especially in symptomatic patients.

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Section: Discussionsupporting

confidence: 91%