P1496: Transferrin Non-Coding Variants Cause Mrna Destabilisation in Congenital Hypotransferrinemia

Abstract

Anemia is a significant public health problem in India, more prevalent in pregnant women and young children. Oral iron is the first-line therapy for IDA in resource constraint settings because of its low cost, perceived safety profile, and ease of administration. Nonetheless, the oral iron absorption is affected by several dietary factors, particularly high phytate content in the Indian diet. Also, the high incidence of gastrointestinal side effects leads to poor compliance to oral Iron therapy which further leads to suboptimal responses. Parenteral iron therapy on the other hand, leads to rapid replenishment of iron stores. The choice of parenteral iron formulation is unclear owing to lack of head-to-head clinical trials in real world resource constraint settings.