P15 Le (E)-2′-déoxy-(fluorométhylène) cytidine (FMdC): un radiosensibilisateur et cytotoxique pour l'application clinique?

Coucke, P. A.; Cottin, E; Yx, Li; Sun, LQ; Ozsahin, M.; Paschoud, Nicolas

doi:10.1016/s1278-3218(97)89603-5

Search citation statements

Order By: Relevance

Paper Sections

Select...

Dntp Concentrations In the Widr Human Colon Carcinoma Cell Line1

Modulation Of Dntp/ntp By Various Anticancer Agents1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1999

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1e is accompanied by a marked increase in TTP, a less pronounced rise of dCTP and dGTP, and a significant overall increase in all four NTPs. A detailed discussion of these findings is reported elsewhere (24,25).…”

Section: Dntp Concentrations In the Widr Human Colon Carcinoma Cell Linementioning

confidence: 78%

“…The detailed pharmacological method will be published elsewhere (24,25). Briefly, exponentially growing WiDr cells were exposed to FMdC (MDL101,731) at concentrations ranging from 0 nM (untreated control cells) to 300 nM for 24 and 48 h. Similarly, WiDr cells were also incubated with IUdR at concentrations ranging from 0.1 to 3 M. Other pharmacological protocols associating various drugs are underway.…”

Section: Modulation Of Dntp/ntp By Various Anticancer Agentsmentioning

confidence: 99%

“…This method was applied for elucidating the activity of the ribonucleoside reductase (RR) inhibitor FMdC (24 -26) administered either alone or in combination with other nucleoside inhibitors, by determining its modulating effect on NTP/dNTP intracellular pool levels of exponentially growing colon carcinoma WiDr cells (24,25).…”

mentioning

confidence: 99%

See 2 more Smart Citations