P1564: The Role of the Necroptosis in Severe Malarial Anemia: Insights From Ripk1 Ablation Models

Abstract

Severe malarial anemia (SMA) is a complication developed during Plasmodium infection. It is often associated with increased rates of malaria-related morbidity and mortality, especially in children and pregnant women. Ineffective erythropoiesis and increased red blood cell destruction are the main features of this disease. Cell death pathways have been proposed as a possible contributor for the hallmarks of the disease, in particularly, the necroptotic pathway.