P16-41. Evidence for in vivo immune selection pressure exerted by HLA class I restricted CTL responses to anti-sense encoded HIV sequences

Berger, Christoph T.; Carlson, Jonathan M.; Brumme, C.J.; Brumme, ZL; Hartman, Kari L.; Henry, LM; Kadie, Carl; Brockman, Mark A.; Harrigan, Richard; Heckerman, David; Brander, C.

doi:10.1186/1742-4690-6-s3-p270

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Autoimmune Hypothesis -Breach Of Tolerance To Native Proteins1

Ribosome Products1

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“…The highly active form of ERAP1 and highly expressed form of ERAP2 is association with disease severity in AS, whereas the loss-of-function of ERAP1 and loss-of expression of ERAP2 is protective in 1 AS (18,92,93). ERAP1 is in epistasis with HLA-B27 and HLA-B40 (18,94), whereas ERAP2 is independently associated with HLA class I molecules (95). The finding that ERAP1 is in epistasis with HLA-B27 and HLA-B40 indicate that these molecules act in the same pathway and mediate disease susceptibility.…”

Section: Autoimmune Hypothesis -Breach Of Tolerance To Native Proteinsmentioning

confidence: 99%

“…The observation that cryptic epitopes can be derived from ribosomal slippage is further supported by studies with viruses. Bypassing the conventional reading frame of the thymidine kinase gene of the herpes simplex virus and genes of human immunodeficiency virus can produce alternative translational products which are recognized by CD8+ T-cells in vitro and in vivo (94,95).…”

Section: Ribosome Productsmentioning

confidence: 99%

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