P1617: Clinical Significance of Cytomegalovirus Drug Resistance Gene Mutations in Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplantation

Refractory cytomegalovirus infections in Chinese patients receiving allogeneic hematopoietic cell transplantation: a review of the literature

“…Data completely characterizing the molecular epidemiology of CMV resistance mutations are lacking in general, and although drug resistance mutations are generally thought to be uncommon, the incidence of such mutations has been reported at up to 14.5% (19,(31)(32)(33); data exploring the prevalence of resistance mutations in Chinese patients with refractory CMV following allo-HCT are also scarce (Table 1). A retrospective study of 41 patients with probable refractory CMV infection following allo-HCT in China found that 20 (49%) had a mutation in UL54 or UL97, and patients with mutations had significantly worse outcomes in terms of clearance of CMV DNAemia; however, only one of the 20 mutations had been previously characterized as a drug-resistance mutation (34). Similarly, a small study in pediatric patients in a Chinese hospital reported 10 novel mutations in UL54, and a retrospective multicenter study of 729 patients reported 12 novel UL54 variants and 1 novel UL97 variant (35).…”