P2.01-45 Clinico-Molecular Characteristics and Prognostic Outcomes of TP53 Mutated Patients with Advanced Non-Small Cell Lung Cancer

Abstract

Inflammation Index (SII) (p ¼ 0.036) as well as decreased levels of MCV (p ¼ 0.025) and total protein (p ¼ 0.049) were significantly associated with reduced overall survival (OS). Furthermore, the higher the Glasgow Prognostic Score (GPS) (p <0.001) or the Lung Prognostic Index (PI-lung) (p <0.001) were the worse was the OS. Failure of first line treatment was significantly predicted by low albumin (p¼0.006), lymphocytes (p ¼ 0.032) and PNI (p ¼ 0.001) levels, whereas low values of CRP (p <0.001), LDH (p ¼ 0.042) and Thrombocyte to Lymphocyte ration (TLR) (p ¼ 0.017) predict response to first line therapy. Multivariate analysis revealed CRP, PI-lung and GPS as independent prognostic factors regardless histology. Conclusion: Simply to obtain blood values and clinical scores provide histology independent markers for response to fist line treatment and survival in stage IV lung cancer patients.