P2.03-034 EGFR Exon 19 Deletion Is Associated with Favorable Overall Survival After First-Line Icotinib Therapy in Advanced NSCLC Patients

Abstract

received osimertinib 80mg once daily. All patients treated with osimertinib received other treatments previously, including EGFR-TKI and standard chemotherapy. The overall response rate (ORR) was 87%. Most common adverse events included diarrhea (28.6%), rash (14.2%), nausea (14.2%). Adverse events of Grade 3 to 4 severity were not reported. Conclusion: These findings suggest that third-line or later osimertinib for advanced lung adenocarcinoma with T790M results in high ORR and managed tolerability. The use of molecular testing may improve treatment outcome in these patients.