P2‐037: Alzheimer'S disease (ad) and mild cognitive impairment (mci) patients are characterized by increased bdnf serum levels

Angelucci, Francesco; Spalletta, Gianfranco; Iulio, Fulvia Di; Ciaramella, Antonio; Salani, Francesca; Colantoni, Luca; Varsi, Ambra Erika; Gianni, Walter; Sancesario, Giuseppe; Caltagirone, Carlo; Bossù, Paola

doi:10.1016/j.jalz.2009.04.346

Cited by 19 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with Angelucci et al [26] and Forlenza et al [27] who reported that serum BDNF concentration is considered as a key player in the activitydependent synaptic plasticity that is involved in the learning and memory processes.…”

Section: El-alameey and Ahmedsupporting

confidence: 92%

Serum Brain Derived Neurotrophic Factor as Biomarker for Epilepsy Diagnosis in Egyptian Children With Epilepsy; Relationship to Disease Severity and Cognitive Function.

El-Alameey

Ahmed

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: This study was designed to estimate serum brain-derived neurotrophic factor (BDNF) concentration in a group of Egyptian children with epilepsy to clarify its utility as a biomarker for epilepsy diagnosis and to evaluate its relationship with their cognitive function and disease severity. Methods:Intelligence was assessed using Arabic version of the WISC-R test. Serum concentration of BDNF was assessed using enzyme-linked immunosorbent assay in 40 children with epilepsy and 40 apparently healthy children of matched age and sex controls.Results: Of total 40 epileptic patients aged 6-12 years, the mean age was 8.32 ± 0.7 years and male to female ratio was 1.5:1. The mean serum BDNF concentration and cognitive IQ scores were statistically significantly reduced in the studied patient's group versus to controls (p<0.001). There were highly significant differences in serum BDNF concentration as regards epileptic severity. Serum concentration of BDNF showed significantly positive correlation with cognitive, verbal, performance, and totals IQ scores and negative correlation with the age at the onset of seizures, and duration of therapy. The linear regression analysis showed a statistically significant association between age at the onset of seizures, duration of therapy, cognitive function, and serum BDNF concentrations among the studied patients. Conclusions:Concentration of BDNF in serum is involved in the mechanism of epileptogenesis in children with epilepsy. It should be used as a helpful marker for epilepsy diagnosis and detection of severity.

show abstract

Section: El-alameey and Ahmedsupporting

confidence: 92%

Serum Brain Derived Neurotrophic Factor as Biomarker for Epilepsy Diagnosis in Egyptian Children With Epilepsy; Relationship to Disease Severity and Cognitive Function.

El-Alameey

Ahmed

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Other results showed increase in the BDNF levels in these patients. Authors suggest that this increase may be an upregulation of BDNF [39,40]. Reductions in the levels of BDNF, NGF and GDNF were observed in 26 patients with moderate AD and 62 with MCI [41].…”

Section: Bdnf and Alzheimer's Diseasementioning

confidence: 98%

“…Increased expression of TrкB was found in CA1 region of the hippocampus of patients in early stages of AD [43]. Other results also demonstrated an increase in the levels of BDNF in both AD and MCI patients, not disease severity or acetylcholinesterase administration dependent [39]. Beyond BDNF, Glycogen synthase kinase-3β (GSK3β) and cAMP-response element-binding protein (CREB) are signaling molecules that can be involved in the neurodegenerative progression [44,45].…”

Section: Bdnf and Alzheimer's Diseasementioning

confidence: 99%

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Budni¹,

Bellettini-Santos²,

Mina³

et al. 2015

Aging and disease

339

188

View full text Add to dashboard Cite

Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cellderived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.

show abstract

“…Neurodegeneration in the brains of AD patients are associated with cognitive impairments (Angelucci et al, 2010). Memory parameters in ICIR rats in the present study were evaluated to assess cognitive impairment; using a RAM, the number of reentries in baited arms by rats was used to assess working memory errors (WME) while reference memory errors (RME) were assessed from the number of entries in unbaited arms (Mizuno et al, 2000).…”

Section: Discussionmentioning

confidence: 98%

A comparison of neurodegeneration linked with neuroinflammation in different brain areas of rats after intracerebroventricular colchicine injection

Sil

Ghosh

Sanyal

et al. 2015

Journal of Immunotoxicology

View full text Add to dashboard Cite

Colchicine induces neurodegeneration, but the extent of neurodegeneration in different areas of the brain in relation to neuroinflammation remains unclear. Such information may be useful to allow for the development of a model to compare colchicine-induced neurodegeneration with other neurodegenerative diseases such as Alzheimer's Disease (AD). The present study was designed to investigate the extent of neurodegeneration along with neuroinflammation in different areas of the brain, e.g. frontal cortex, parietal cortex, occipital cortex, corpus striatum, amygdala and hippocampus, in rats along with memory impairment 21 days after a single intracerebroventricular (icv) injection of colchicine. Memory parameters were measured before and after icv colchicine injection in all test groups of rats (control, sham-operated, colchicineinjected [ICIR] rats). On Day 21 post-injection, rats from all groups were anesthesized and tissues from the various brain areas were collected for assessment of biomarkers of neuroinflammation (i.e. levels of ROS, nitrite and proinflammatory cytokines TNF and IL-1) and neurodegeneration (assessed histologically). The single injection of colchicine resulted in impaired memory and neurodegeneration (significant presence of plaques, Nissl granule chromatolysis) in various brain areas (frontal cortex, amygdala, parietal cortex, corpus striatum), with maximum severity in the hippocampus. While IL-1, TNF, ROS and nitrite levels were altered in different brain areas in the ICIR rats, these parameters had their greatest change in the hippocampus. This study showed that icv injection of colchicine caused strong neurodegeneration and neuroinflammation in the hippocampus of rats and the increases in neurodegeneration were corroborated with those of neuroinflammation at the site. The present study also showed that the extent of neurodegeneration and neuroinflammation in different brain areas of the colchicine-injected rats were AD-like and supported the fact that such rats might have the ability to serve as a sporadic model of AD.

show abstract

P2‐037: Alzheimer'S disease (ad) and mild cognitive impairment (mci) patients are characterized by increased bdnf serum levels

Cited by 19 publications

References 37 publications

Serum Brain Derived Neurotrophic Factor as Biomarker for Epilepsy Diagnosis in Egyptian Children With Epilepsy; Relationship to Disease Severity and Cognitive Function.

Serum Brain Derived Neurotrophic Factor as Biomarker for Epilepsy Diagnosis in Egyptian Children With Epilepsy; Relationship to Disease Severity and Cognitive Function.

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

A comparison of neurodegeneration linked with neuroinflammation in different brain areas of rats after intracerebroventricular colchicine injection

Contact Info

Product

Resources

About