P2‐292: Mild Behavioral Impairment (Mbi) in McI, Scd, and Normal Elderly: A Pilot Study for Validation of the Mild Behavioral Impairment Checklist (Mbi‐c)

Kang, Yeonwook; Chin, Juhee; Han, Noel; Park, Jaeseol; Yeom, Jiyoung; Yang, Soh-Jeong; Ryu, Hui Jin; Lee, Byung Hwa; Yoo, Rayoung; Ahn, Yisuh; Ismail, Zahinoor

doi:10.1016/j.jalz.2018.06.981

Cited by 12 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…113 The case ascertainment instrument for MBI was developed specifically for functionally intact community dwelling older adults, and has also been validated. 94,[114][115][116][117][118][119]…”

Section: Behavioral Markers For Late-onset Dementiamentioning

confidence: 99%

CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus

Montero‐Odasso

Pieruccini‐Faria

Ismail

et al. 2020

A&D Transl Res & Clin Interv

Self Cite

View full text Add to dashboard Cite

Introduction Cognitive impairment is the hallmark of Alzheimer's disease (AD) and related dementias. However, motor decline has been recently described as a prodromal state that can help to detect at‐risk individuals. Similarly, sensory changes, sleep and behavior disturbances, and frailty have been associated with higher risk of developing dementia. These clinical findings, together with the recognition that AD pathology precedes the diagnosis by many years, raises the possibility that non‐cognitive changes may be early and non‐invasive markers for AD or, even more provocatively, that treating non‐cognitive aspects may help to prevent or treat AD and related dementias. Methods A subcommittee of the Canadian Consensus Conference on Diagnosis and Treatment of Dementia reviewed areas of emerging evidence for non‐cognitive markers of dementia. We examined the literature for five non‐cognitive domains associated with future dementia: motor, sensory (hearing, vision, olfaction), neuro‐behavioral, frailty, and sleep. The Grading of Recommendations Assessment, Development, and Evaluation system was used to assign the strength of the evidence and quality of the recommendations. We provide recommendations to primary care clinics and to specialized memory clinics, answering the following main questions: (1) What are the non‐cognitive and functional changes associated with risk of developing dementia? and (2) What is the evidence that sensory, motor, behavioral, sleep, and frailty markers can serve as potential predictors of dementia? Results Evidence supported that gait speed, dual‐task gait speed, grip strength, frailty, neuropsychiatric symptoms, sleep measures, and hearing loss are predictors of dementia. There was insufficient evidence for recommending assessing olfactory and vision impairments as a predictor of dementia. Conclusions Non‐cognitive markers can assist in identifying people at risk for cognitive decline or dementia. These non‐cognitive markers may represent prodromal symptoms and several of them are potentially amenable to treatment that might delay the onset of cognitive decline.

show abstract

Section: Behavioral Markers For Late-onset Dementiamentioning

confidence: 99%

CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus

Montero‐Odasso

Pieruccini‐Faria

Ismail

et al. 2020

A&D Transl Res & Clin Interv

Self Cite

View full text Add to dashboard Cite

show abstract

“…Of the five MBI domains, the impulse dyscontrol domain provides assessment of agitation, aggression, and impulsivity symptoms. The MBI‐C is the first measure developed specifically for the pre‐dementia population, and the ongoing validation studies 42,80–85 will determine its diagnostic utility. Early validation results have determined cut‐points for MBI diagnosis in SCD 85,86 and MCI, and have demonstrated a five‐factor model for the MBI‐C with an intact impulse control/agitation domain, 42,87 test‐retest reliability, construct validity, and discriminative validity from the NPI 84,85 .…”

Section: Diagnosis and Measurementmentioning

confidence: 99%

“…The MBI‐C is the first measure developed specifically for the pre‐dementia population, and the ongoing validation studies 42,80–85 will determine its diagnostic utility. Early validation results have determined cut‐points for MBI diagnosis in SCD 85,86 and MCI, and have demonstrated a five‐factor model for the MBI‐C with an intact impulse control/agitation domain, 42,87 test‐retest reliability, construct validity, and discriminative validity from the NPI 84,85 . Furthermore, a 1‐year longitudinal study has shown the emergence of MBI with cognitive decline in cognitively normal older adults 42 …”

Section: Diagnosis and Measurementmentioning

confidence: 99%

Agitation and impulsivity in mid and late life as possible risk markers for incident dementia

Bateman

Gill

et al. 2020

A&D Transl Res & Clin Interv

Self Cite

View full text Add to dashboard Cite

To identify knowledge gaps regarding new‐onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimer's Research and Treatment Neuropsychiatric Syndromes (NPS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre‐dementia risk syndrome Mild Behavioral Impairment (MBI), we focused on late‐onset agitation and impulsivity (the MBI impulse dyscontrol domain) and risk of incident cognitive decline and dementia. This scoping review of agitation and impulsivity pre‐dementia syndromes summarizes the current biomedical literature in terms of epidemiology, diagnosis and measurement, neurobiology, neuroimaging, biomarkers, course and prognosis, treatment, and ongoing clinical trials. Validations for pre‐dementia scales such as the MBI Checklist, and incorporation into longitudinal and intervention trials, are needed to better understand impulse dyscontrol as a risk factor for mild cognitive impairment and dementia.

show abstract

“…Further, the MBI-C has demonstrated internal consistency, test-retest reliability (Mallo et al, 2018c), and discriminative validity from the NPI (Kang et al, 2018;Mallo et al, 2018c). In terms of imaging and biomarker validations, the MBI-C is associated with worsening cognition and temporal lobe atrophy in those with Parkinson's Disease (Monchi et al, 2018).…”

Section: Introductionmentioning

confidence: 98%

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

Creese

Griffiths

Brooker

et al. 2019

Int. Psychogeriatr.

Self Cite

View full text Add to dashboard Cite

ABSTRACTObjectives:In this large population study, we set out to examine the profile of mild behavioral impairment (MBI) by using the Mild Behavioral Impairment Checklist (MBI-C) and to explore its factor structure when employed as a self-reported and informant-rated tool.Design:This was a population-based cohort study.Setting:Participants were recruited from the Platform for Research Online to Investigate Genetics and Cognition in Aging study (https://www.protect-exeter.org.uk).Participants:A total of 5,742 participant-informant dyads participated in the study.Measurements:Both participants and informants completed the MBI-C. The factor structure of the MBI-C was evaluated by exploratory factor analysis.Results:The most common MBI-C items, as rated by self-reported and informants, related to affective dysregulation (mood/anxiety symptoms), being present in 34% and 38% of the sample, respectively. The least common items were those relating to abnormal thoughts and perception (psychotic symptoms) (present in 3% and 6% of the sample, respectively). Only weak correlations were observed between self-reported and informant-reported MBI-C responses. Exploratory factor analysis for both sets of respondent answers indicated that a five-factor solution for the MBI-C was appropriate, reflecting the hypothesized structure of the MBI-C.Conclusion:This is the largest and most detailed report on the frequency of MBI symptoms in a nondementia sample. The full spectrum of MBI symptoms was present in our sample, whether rated by self-reported or informant report. However, we show that the MBI-C performs differently in self-reported versus informant-reported situations, which may have important implications for the use of the questionnaire in clinic and research.

show abstract

P2‐292: Mild Behavioral Impairment (Mbi) in McI, Scd, and Normal Elderly: A Pilot Study for Validation of the Mild Behavioral Impairment Checklist (Mbi‐c)

Cited by 12 publications

References 0 publications

CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus

CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus

Agitation and impulsivity in mid and late life as possible risk markers for incident dementia

Profile of mild behavioral impairment and factor structure of the Mild Behavioral Impairment Checklist in cognitively normal older adults

Contact Info

Product

Resources

About