P21-15 Burning mouth syndrome — a peripheral small fiber neuropathy

Puhakka, Antti; Forssell, Heli; Soinila, Seppo; Jääskeläinen, SK

doi:10.1016/s1388-2457(10)60939-x

Cited by 9 publications

(17 citation statements)

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“…Other studies using tQST have demonstrated similar alterations in thermal sensory detection thresholds, most often negative sensory signs in small‐fibre‐mediated sensory modalities (thermal hypoesthesia or anaesthesia) (Svensson et al , ; Forssell et al , ; Ito et al , ; Granot and Nagler, ; Puhakka et al , ), but also positive sensory signs in the form of thermal allodynia or decreased heat pain tolerance have been detected in a minority of patients (Forssell et al , ; Granot and Nagler, ; Gremeau‐Richard et al , ). In the study by Just et al () , the lingual nerve sensitivity was tested with capsaicin threshold tests.…”

Section: Somatosensory System Dysfunction In Bmsmentioning

confidence: 75%

“…In line with the tQST evidence for focal small fibre hypofunction, several small studies have demonstrated the loss of epithelial nerve fibres in tongue mucosal biopsies of BMS patients, giving further evidence for a peripheral neuropathic process affecting the small nerve fibres in BMS (Lauritano et al, 1998;Yilmaz et al, 2007;Forssell et al, 2008;Beneng et al, 2010;Penza et al, 2010;Puhakka et al, 2010). Most interestingly, detailed immunohistochemical analyses of the tongue mucosal biopsies from BMS patients have revealed significant overexpression of pro-nociceptive ion channels (TRPV1) and purinergic receptors (P2X 3 ) in the spared subepithelial myelinated nerve fibres in the tongue mucosa of BMS patients (Yilmaz et al, 2007;Beneng et al, 2010).…”

Section: Oral Diseasesmentioning

confidence: 80%

“…BR recordings with stimulation of the distal branches of the third trigeminal division in primary BMS patients have revealed distinct abnormalities within the trigeminofacial large and small fibre systems and the trigeminal brainstem complex (Jääskeläinen et al , ; Forssell et al , ; Puhakka et al , ). In a large study with 52 primary BMS patients, the results of the BR studies indicated subclinical brainstem pathology or peripheral trigeminal neuropathy, mostly lingual or mandibular nerve lesions, in 20% of the patients (Forssell et al , ).…”

Section: Somatosensory System Dysfunction In Bmsmentioning

confidence: 99%

“…In addition to hypofunction of the focal small fibre system, the findings of several studies have indicated a more generalized disorder of the somatosensory system in BMS patients (Svensson et al , ; Lauritano et al , ; Lauria et al , ; Gremeau‐Richard et al , ; Puhakka et al , ). In a recent study using extensive neurophysiologic and psychophysical examinations of the distal extremities in addition to the study of the trigeminal system, 90% of the BMS patients showed neurophysiologic or tQST signs of a more generalized nervous system disorder (Puhakka et al , ).…”

Section: Somatosensory System Dysfunction In Bmsmentioning

confidence: 99%

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Pathophysiology of primary burning mouth syndrome with special focus on taste dysfunction: a review

et al. 2015

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Primary burning mouth syndrome (BMS) is a chronic oral condition characterized by burning pain often accompanied with taste dysfunction and xerostomia. The most compelling evidence concerning BMS pathophysiology comes from studies on the somatosensory system using neurophysiologic or psychophysical methods such as blink reflex, thermal quantitative sensory testing, as well as functional brain imaging. They have provided convincing evidence for neuropathic involvement at several levels of the somatosensory system in BMS pain pathophysiology. The number of taste function studies trying to substantiate the subjective taste disturbances or studies on salivary factors in BMS is much more limited, and most of them suffer from definitional and methodological problems. This review aims to critically evaluate the existing literature on the pathophysiology of BMS, paying special attention to the correctness of case selection and the methodology used in published studies, and to summarize the current state of knowledge. Based on the recognition of several gaps in the current understanding of the pathophysiology of BMS especially as regards taste and pain system interactions, the review ends with future scenarios for research in this area.

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Section: Somatosensory System Dysfunction In Bmsmentioning

confidence: 75%

Section: Oral Diseasesmentioning

confidence: 80%

Section: Somatosensory System Dysfunction In Bmsmentioning

confidence: 99%

Section: Somatosensory System Dysfunction In Bmsmentioning

confidence: 99%

See 2 more Smart Citations

Pathophysiology of primary burning mouth syndrome with special focus on taste dysfunction: a review

et al. 2015

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“…3,18,19 The number of fibers is inversely correlated to the symptom(s) duration. 3 In addition, there is an up-regulation of TRPV1 (transient receptor potential vanilloid 1) receptor, and P2X3, a purinergic receptor, which has been associated with symptoms of burning tongue.…”

Section: Peripheral Nerve Abnormalities/sensitizationmentioning

confidence: 99%

Burning Mouth Syndrome

Ducasse

Courtet

Olié

2013

Regional Anesthesia and Pain Medicine

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Primary burning mouth syndrome (BMS) is defined as an "intraoral burning for which no medical or dental cause was found." Lifetime prevalence ranges from 3.7% to 18% - 40% in the elderly. There is no consensus among experts on the diagnostic criteria of BMS, the etiology is poorly understood, and there are no existing clinical guidelines. Therefore, BMS is often underdiagnosed and its management complex. For patients with BMS, this lack of clinical expertise may result in decreased quality of life and increased psychological distress.We conducted a systematic review to identify clinical features, pathophysiology, and therapeutic strategies for BMS. We discuss the multifactorial origin, involving peripheral nerve dysfunction and hormonal dysfunction, as well as psychological traits. We also describe the results of randomized clinical trials for each treatment through a pathophysiologic approach. This review should help clinicians recognize BMS, understand its pathophysiology, and gain an enhanced scientific understanding of therapeutic alternatives.

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La douleur orofaciale idiopathique: une douleur fonctionnelle

Bodéré¹,

Woda

2009

Douleur analg

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Le concept d'algie orofaciale idiopathique (AOFI) regroupe plusieurs douleurs chroniques de l'extrémité céphalique qui sont souvent très invalidantes (algie faciale atypique, odontalgie atypique, stomatodynie, certaines douleurs musculosquelettiques). Ces pathologies localisées autour de la cavité buccale ne correspondent à aucune cause organique objectivable et pourraient être assimilées à des douleurs « fonctionnelles ». Elles pourraient constituer une seule et même entité physiopathologique affectant des tissus différents. Différents mécanismes physiopathologiques démontrés ou hypothétiques sont décrits.Mots clés Douleur orofaciale idiopathique · Douleur fonctionnelle · Douleur myofasciale · Douleur neuropathique · Arthromyalgie · Stomatodynie Abstract The concept of orofacial idiopathic pain groups together several chronic pain syndromes of the head, which are often very disabling (atypical facial pain, atypical odontalgia, stomatodynia, certain forms of musculoskeletal pain). These orofacial pathologies are not associated with somatic identifiable causes and could be considered as "functional" pain. Such entities might constitute a single pathophysiological entity affecting different tissues. Different pathophysiological mechanisms, already demonstrated or hypothetical, are presented.

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P21-15 Burning mouth syndrome — a peripheral small fiber neuropathy

Cited by 9 publications

References 0 publications

Pathophysiology of primary burning mouth syndrome with special focus on taste dysfunction: a review

Pathophysiology of primary burning mouth syndrome with special focus on taste dysfunction: a review

Burning Mouth Syndrome

La douleur orofaciale idiopathique: une douleur fonctionnelle

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