P244 The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke

Abstract

. (2017). P244 The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke. CLINICAL NEUROPHYSIOLOGY, 128(3), e133. DOI: 10.1016DOI: 10. /j.clinph.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policyIf you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.  Improvement in the Jebsen Taylor Test was seen after unilateral motor cortex tDCS but not after bihemispheric motor cortex tDCS. Changes in performance with tDCS were independent of changes in transcallosal inhibition. AbstractObjective: To assess the impact of electrode arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements.Methods: 24 stroke survivors (3-124 months post-stroke) with upper limb impairment participated. They received blinded tDCS during a motor sequence learning task, requiring the paretic arm to direct a cursor to illuminating targets on a monitor. Four tDCS conditions were studied (crossover); anodal to ipsilesional M1, cathodal to contralesional M1, bihemispheric, sham. The Jebsen Taylor hand function test (JTT) was assessed pre-and poststimulation and TCI assessed as the ipsilateral silent period (iSP) duration using transcranial magnetic stimulation. Results:The time to react to target illumination reduced with learning of the movement se...