P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

Lu, Zhikun; Xu, Yufen; Fu, Lanyan; Tan, Yaqian; Che, Di; Huang, Ping; Pi, Lei; Zhou, Huazhong; Liang, Xiaofeng; Zhang, Li; Gu, Xiaoqiong

doi:10.1002/jgm.3066

Cited by 10 publications

(11 citation statements)

References 39 publications

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“…Many studies have shown that P2RY12 may be a protective factor for clopidogrel and aspirin resistance [19,20]. As we described previously [21], the P2RY12: rs7637803 TT variant genotype increased the risk of coronary artery aneurysm in KD patients in a southern Chinese population. However, no studies have focused on the connection between the P2RY12 polymorphism and IVIG resistance in KD.…”

Section: Introductionsupporting

confidence: 62%

“…However, because the five SNPs in the P2RY12 gene are associated with aspirin and clopidogrel resistance, based on this background, we investigated whether the five SNPS were a relationship between P2RY12 polymorphisms and IVIG resistance in KD patients. A previous study by our research group focused on the relationship between P2RY12 polymorphism with KD genetic susceptibility and coronary artery aneurysm (CAA) complications [21]. e study found that rs7637803 significantly increased CAA risk in KD patients.…”

Section: Discussionmentioning

confidence: 99%

“…We preset 0.2 as the false-positive report probability (FPRP) threshold and chose a prior probability of 0.1 to detect OR of 0.67 (for protective effects). e statistical analyses procedures have been described previously [21]. Table 1 shows the demographic characteristics of KD cases that were resistant or sensitive to IVIG therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Li et al [20] showed that the rs2046934 C allele may be a protective factor in clopidogrel resistance, rs2046934 was included as one of the variations in the P2RY12 gene that was examined and was found to contribute to interindividual variability during clopidogrel therapy. Lu et al [21] found that rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki Disease in a Southern Chinese Population, the rs7637803 genotype might be used as a biomarker to predict the occurrence of coronary artery aneurysm in KD patients. Zhang et al [30] found that the rs6809699 minor allele could predict bleedings in ST-elevation myocardial infarction patients after percutaneous coronary intervention.…”

Section: Discussionmentioning

confidence: 99%

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Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients

Wang

Zhou

et al. 2020

Cardiovascular Therapeutics

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Children with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG) have a higher incidence of coronary artery lesions (CAL). Despite the association between Purinergic receptor P2Y12 (P2RY12) polymorphism, KD genetic susceptibility, and CAL complications being proved, few studies have assessed the relationship between P2RY12 polymorphisms and IVIG resistance in patients with KD. We recruited 148 KD patients with IVIG resistance and 611 with IVIG sensitivity and selected five P2RY12 polymorphisms: rs9859538, rs1491974, rs7637803, rs6809699, and rs2046934. A significant difference in the genotype distributions between patients was only observed for the rs6809699 A > C polymorphism (AC vs. AA: adjusted odds ratio (OR) = 0.48, 95% confidence interval (CI) = 0.27–0.84, P=0.011; AC/CC vs. AA: adjusted OR = 0.47, 95% CI = 0.27–0.83, P=0.0084). After adjusting for age and gender, the carriers of the rs6809699 C allele had OR of 0.44 to 0.49 for IVIG sensitivity (AC vs. AA: adjusted OR = 0.48, 95% confidence interval (CI) = 0.27–0.84, P=0.011; AC/CC vs. AA: adjusted OR = 0.47, 95% CI = 0.27–0.83, P=0.0084) compared to the carriers of a rs6809699 AA genotype, suggesting the protective effect of this SNP against IVIG resistance. Moreover, individuals with all five protective polymorphisms experienced a significantly decreased IVIG resistance compared to that of individuals with up to three protective polymorphisms (adjusted OR = 0.27, 95% CI = 0.13–0.57, P=0.0006). Our results suggest that the P2RY12 rs6809699 polymorphism could be used as a biomarker to predict IVIG resistance in KD patients.

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Section: Introductionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients

Wang

Zhou

et al. 2020

Cardiovascular Therapeutics

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“…There is growing evidence that genetic polymorphisms are important determinants of CAAs in KD, which could result in predispositions to adverse outcomes [ 29 – 31 ]. However, there is less evidence about the relation between platelet receptor gene polymorphisms and KD, especially coronary artery abnormality.…”

Section: Discussionmentioning

confidence: 99%

Impact of Platelet Glycoprotein Ia/IIa C807T Gene Polymorphisms on Coronary Artery Aneurysms of KD Patients

Yuan

et al. 2021

Cardiology Research and Practice

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Background. Kawasaki disease (KD) is a systemic vasculitis of unknown etiology in children. Coronary artery abnormalities are the most common complications of KD. Recent evidence showed that genetic polymorphisms may lead to susceptibility to KD. Genetic variants in platelet glycoprotein have been reported to be associated with coronary artery disease. The aim of the present study is to investigate the correlation between the role of platelet glycoprotein and coronary artery aneurysms in KD patients. Methods. We did a case-control study that enrolled 818 KD patients and 1401 healthy children with the same age and sex from January 2013 to December 2016. Analysis of single-nucleotide polymorphism (rs1126643) of the platelet glycoprotein Ia/IIa C807T was performed by multiplex polymerase chain reactions in this study. Results. A significant difference in the genotype distribution between KD cases and controls was observed for the glycoprotein Ia/IIa C807T (rs1126643) polymorphism ( p = 0.026 ). Compared with the healthy children, the rs1126643T allele carriers had odds ratio (OR) of 0.63 for developing KD (TT vs. CC: adjusted OR = 0.62, 95% confidence interval (CI) = 0.43–0.88, p = 0.0078 ; TT vs. CT/CC: adjusted OR = 0.63, 95% CI = 0.44–0.889, p = 0.0093 ). Furthermore, we also found that children less than 60 months of age and female patients with rs1126643 T allele carriers had an adjusted OR of 0.66 (95% CI = 0.46–0.95) for noncoronary artery aneurysm patients ( p = 0.0242 ). Single-nucleotide polymorphism rs1126643 TT seems to represent a protective factor against KD in coronary artery aneurysm formation in multivariate analysis. Conclusions. The platelet glycoprotein Ia/IIa T allele carriers may have a protective effect on the risk of coronary artery aneurysms of KD patients, especially in females and children aged less than 60 months. These results may provide evidence for platelet glycoprotein Ia/IIa gene polymorphisms in the pathogenesis of KD patients.

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A LncRNA gene polymorphism (rs1814343) is associated with the risk of coronary artery lesions in southern Chinese Kawasaki disease patients

Chen

Tian

et al. 2023

The Journal of Gene Medicine

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Background Kawasaki disease (KD) is a multisystemic angiitis, and its most disastrous complication is coronary artery lesions (CALs). Recently, the role of long non‐coding RNAs (lncRNAs) in KD has been reported. rs1814343 is a lncRNA, but the relationship between the lncRNA rs1814343 polymorphism and KD risk remains elusive. Methods We enrolled 1625 Kawasaki disease patients (583 patients with CAL and 1042 without CAL) and 1000 healthy controls from a southern Chinese population. We genotyped the rs1814343 C > T polymorphism in KD and control patients using the TaqMan method. The odds ratio (OR) and 95% confidence interval (CI) were used to estimate the strength of the association. Results There was no significant association between the lncRNA rs1814343 C > T polymorphism and KD susceptibility. However, we stratified patients in this study by CAL and sex. First, compared with the control groups, we found that the rs1814343 genotype increased risk for KD patients with CAL (TT vs. CC + CT: OR = 1.36, 95% CI = 1.08–1.71, p = 0.009). Moreover, when KD patients were stratified by CAL, the TT genotypes of this lncRNA polymorphism contributed to a relatively higher occurrence of KD with CAL than that was found in the CC/CT genotype patients (TT vs. CC + CT: OR = 1.35, 95% CI = 1.07–1.69, p = 0.011). In addition, our research suggested that the TT variant genotype in the lncRNA rs1814343 had an obvious risk of KD with CAL susceptibility in male children. Conclusion The lncRNA rs1814343 C > T polymorphism was related to higher susceptibility of KD with CAL.

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P2RY12:rs7637803 TT variant genotype increases coronary artery aneurysm risk in Kawasaki disease in a southern Chinese population

Cited by 10 publications

References 39 publications

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients

Impact of Platelet Glycoprotein Ia/IIa C807T Gene Polymorphisms on Coronary Artery Aneurysms of KD Patients

A LncRNA gene polymorphism (rs1814343) is associated with the risk of coronary artery lesions in southern Chinese Kawasaki disease patients

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