“…Finally, P2X7 promotes autophagy [ 17 , 44 , 106 , 107 , 108 ] and unfolded protein responses [ 113 ], which help confer metabolic and immune evasive plasticity in solid cancers [ 90 ]. Given the involvement of the P2X7 receptor in the aforementioned metastasis-promoting signaling pathways and mechanisms, it is not surprising that overexpression of the receptor was associated with metastatic stages of multiple cancers [ 43 , 55 , 101 , 114 , 115 , 116 , 117 , 118 ]. Accordingly, P2X7 antagonism proved efficacious in reducing the in vivo dissemination of cancer cells in animal models of metastasis [ 41 , 43 , 78 , 91 , 92 , 96 , 119 ].…”