P3.16.23 Malignant transformation of mature teratomas‐report of two cases

Abstract

Results: 208 patients were included. The mean age was 24 years (range 7-64), median age was 23 years, median follow up time was 39 months (range l-288). Histology were confirmed MOGCI included dysgerminoma for 62 patients, non-dysgerminoma for 146 patients. All patients underwent operation: radical surgery for 118 patients (56.73%) and fertility sparing surgery for 90 patients (43.27%). According to FIG0 1987 staging system; 89,25, 67 and 27 patients were classified in stage I, II, III and IV respectively. 195 patients were treated by chemotherapy but evaluable patients were achieved in 167 patients. Outcomes of these patients were complete response 133 patients (79.6%). Failure to fist line chemotherapy occurred in 44 patients (29.3%) mostly in non-dysgerminoma but only 10 of 44 (22.7%) were completely responded to second line chemotherapy and still free of disease. Recurrence occurred in 11 patients (6.4%) but 7 out of 11 patients (63.6%) who relapsed were successful salvaged.Overall 5-year survival rate was 80.77%. The 5-year survival rate for dysgerminoma and non-dysgerminoma were 93.8 and 72.9% respectively. The 5-year survival rate for radical and conservative surgery were 77 and 81% (P>O.O5). In analysis of prognostic factors for survival showed that advanced stage and non-dysgerminoma were independent prognostic factors (P<O.O5). Conclusions: This retrospective review is one of a large series to understand natural history, outcomes and prognostic factors. Advanced stage and non-dysgerminoma remained the most significantly adverse prognostic factors. Conservative surgery or fertility sparing surgery must be considered and did not affect overall survival outcome in malignant ovarian germ cell tumors.