P3‐172: Apoe E4 Stratification of Alzheimer's Disease Patients Defines Two Distinct Sets of Plasma Metabolomics Markers Related to Lipid or Mitochondrial Metabolism Dysfunction

Abstract

changes in concentration of and in the CSF and plasma of 5-, 7-, 9-and 12-month-old female transgenic mice using sandwich-ELISA to define a relationship between the plasma Ab and AD progression and, also, to confirm the diagnostic potential of the plasma Ab prior to the plaque formation. Results: We found that plasma Ab(1-42) concentration increases with age, while the concentration of Ab(1-42) in the cerebrospinal fluid (CSF) decreases in 3xTg-AD mice, if measurements were made before formation of ThS-positive plaques in the brain. Conclusions:There is an inverse correlations between the plasma and CSF Ab(1-42) levels until plaques form in transgenic mice's brains and that the plasma Ab concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.