P3–293: Effects of cognitive training and rTMS in Alzheimer's disease

Brem, Anna-Katharine; Schilberg, Lukas; Freitas, Catarina; Atkinson, Natasha; Seligson, Erica; Pascual‐Leone, Álvaro

doi:10.1016/j.jalz.2013.05.1367

Cited by 13 publications

(31 citation statements)

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“…Of these studies, nine were RCTs with a parallel control design and four had a crossover design. The data from seven parallel‐group RCTs with complete outcome data (Cotelli et al , ; Ahmed et al , ; Brem et al , ; Rabey et al , ; Drumond Marra et al , ; Wu et al , ; Lee et al , ) were synthesised in the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Only two studies targeted subjects with MCI (Turriziani et al , ; Drumond Marra et al , ). In three studies, no concomitant psychotropic medication was used (Ahmed et al , ; Turriziani et al , ; Drumond Marra et al , ); in seven studies, the participants took cognition‐enhancing drugs for dementia (Cotelli et al , ; Cotelli et al , ; Brem et al , ; Rabey et al , ; Ash et al , ; Rutherford et al , ; Lee et al , ); and in one study, risperidone was used to control behavioural and psychological symptoms of dementia (Wu et al , ) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Most studies used a figure‐of‐eight coil, one study used an H‐coil (Coppi et al , ) and three studies did not report which type of coil was used (Ash et al , ; Rutherford et al , ; Lee et al , ). All studies involved the frontal/prefrontal region as the TMS target sites: seven studies used the DLPFC as the sole target (either unilaterally or bilaterally) (Cotelli et al , ; Cotelli et al , ; Ahmed et al , ; Turriziani et al , ; Drumond Marra et al , ; Rutherford et al , ; Wu et al , ); three studies targeted the same combination of sites involving Broca's area, Wernicke's area, the DLPFC and the parietal cortex (Brem et al , ; Rabey et al , ; Lee et al , ). Coppi et al () and Ash et al () reported using the fronto‐parietal–temporal lobes and prefrontal areas, respectively, without specifying the exact target site.…”

Section: Resultsmentioning

confidence: 99%

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Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis

Cheng

Wong

Lee

et al. 2017

Int J Geriat Psychiatry

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Objective: This systematic review and meta-analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment. Methods: A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini-Mental State Examination or the Alzheimer's Disease Assessment Scale-cognitive subscale. Results: Seven RCTs were included in the meta-analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84). Conclusions: High-frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well-tolerated alternative intervention for cognition.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta‐analysis

Cheng

Wong

Lee

et al. 2017

Int J Geriat Psychiatry

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“…rTMS could offer a reliable method to characterize important neurophysiological and physiopathological aspects of AD, and a decrease in cortical plasticity and connectivity/reactivity has been identified in comparison with healthy persons and even with other dementias. As a result, rTMS can be proposed as a promising therapy for AD (Bentwich et al, 2011;Brem et al, 2013;Freitas et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…It is also necessary to determine how long the effect remains for the different modalities of application, and the number of sessions required for treatment, since AD is a chronic, degenerative process, which makes it different from other conditions such as depression, which are resistant to treatment, for which rTMS has already been approved as a method of treatment by the FDA (Brem et al, 2013;Freitas et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

An overview of repetitive transcranial magnetic stimulation (rTMS) in Alzheimer’s disease

Santana

Rojas

et al. 2017

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Background. Alzheimer's disease (AD) is the most frequent neurocognitive disorder. It affects 50% to 75% of the cases of dementia, and is characterized by a progressive cognitive decline that hinders behavior and functionality. Its etiology is still uncertain, and the efficiency of treatments is limited. Repetitive transcranial magnetic stimulation (rTMS) has been used as an alternative therapeutic strategy, but the clinical impact on Alzheimer's disease has hardly been studied. Objective. To describe the effects of rTMS on cognition, the behavioral and psychological symptoms of dementia (BPSD), and functionality, considering the various modes of application. Method. The PubMed, ScienceDirect, and PsycInfo databases were consulted using key words relating to the topic of study. Articles published between 2006 and 2016 were selected. Results. The studies that have assessed the clinical effect of rTMS have used various parameters to stimulate and compare the different cortical areas, principally the dorsolateral prefrontal cortex. A variety of benefits have been proposed for patients with Alzheimer's disease in cognitive domains such as language and episodic memory, as well as behavior and functionality in everyday activities. Discussion and conclusion. rTMS has been suggested as a possible treatment for AD, and the results indicate the need for further studies with different methodological designs and more participants, in addition to cognitive rehabilitation techniques. The objective is to identify the most efficient parameters for stimulation and to explore new cortical targets.

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