Background: Previous studies have shown that depression is associated with cognitiveimpairment. However, others have shown that there is no significant difference in the scoresof the National Adult Reading Test (NART), a screening test for intellectual functioning andgeneral level of education, between those with vs. without depression. This study sought toexamine whether depression is associated with the American version of NART (AMNART) ina rural cohort of West Texas.Methods: Participants with IQ and AMNART tests were selected from Project FRONTIER,an ongoing epidemiology study of rural residents in four West Texas counties.Results: AMNART scores were significantly lower in participants with depression(23.3±9.2) vs. those without depression (25.9±9.9) (p<0.05). Analysis by age group showedthat AMNART scores were significantly lower in those with depression (22.0±10.1) comparedwith those without depression (26.2±10.2) in the age group 50 to 64 years (P=0.0322). AlthoughAMNART scores were lower in participants with depression than those without depression inthe age groups 40 to 49 years (25.0±8.6 vs. 26.2±10.2) and 65 years or older (23.6±8.2 vs.25.6±9.5), they were not statistically significantly different.Conclusions: Depression is associated with lower AMNART scores in rural residentsaged between 50 and 64 years in West Texas.