[P3–418]: PARIETAL WHITE MATTER LESIONS IN ALZHEIMER's DISEASE ARE ASSOCIATED WITH CORTICAL NEURODEGENERATIVE PATHOLOGY AND NOT WITH SMALL‐VESSEL DISEASE

McAleese, Kirsty E.; Walker, Lauren; Graham, Sophie; Erskine, Daniel; Moya, Elisa L.J.; Johnson, Mary Ann; Colloby, Sean J.; Dey, Madhurima; Taylor, John‐Paul; Thomas, Alan; McKeith, Ian; DeCarli, Charles; Attems, Johannes

doi:10.1016/j.jalz.2017.06.1635

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“…However, when analyzing the individual risk factors, we did not find an association between systolic blood pressure and antihypertensive medication use with deep WMHs either. Possibly, other factors than small vessel disease contribute to the occurrence of deep WMHs, such as Wallerian degeneration (McAleese et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

White matter hyperintensities and vascular risk factors in monozygotic twins

Kate

Sudre

Braber

et al. 2018

Neurobiology of Aging

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a b s t r a c tCerebral white matter hyperintensities (WMHs) have been associated with vascular risk factors, both of which are under genetic influence. We examined in a monozygotic twin sample whether the association between vascular risk and WMHs is influenced by overlapping genetic factors. We included 195 cognitively normal monozygotic twins (age ¼ 70 AE 7 years), including 94 complete pairs. Regional WMH load was estimated using an automated algorithm. Vascular risk was summarized with the Framingham score. The withinetwin pair correlation for total WMHs was 0.76 and for Framingham score was 0.77. Within participants, Framingham score was associated with total and periventricular WMHs (r ¼ 0.32). Framingham score in 1 twin was also associated with total WMHs in the co-twin (r ¼ 0.26). Up to 83% of the relation between both traits could be explained by shared genetic effects. In conclusion, monozygotic twins have highly similar vascular risk and WMH burden, confirming a genetic background for these traits. The association between both traits is largely driven by overlapping genetic factors.

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Section: Discussionmentioning

confidence: 99%